Oxicams: relative safety and anti-injury effects in rats.
作者信息
Whitehouse M W
出版信息
Br J Clin Pharmacol. 1986;22 Suppl 2(Suppl 2):111S-116S. doi: 10.1111/j.1365-2125.1986.tb02990.x.
Abstract
1 Oxicams have certain distinctive properties, which distinguish them from other arylalkanoic (carboxylic) acids that show anti-inflammatory/analgesic/antipyretic activities. These include: (i) slow rates of metabolism (ii) lesser gastro-irritancy/ulcerogenicity (iii) preventing fever development (iv) some effect on the adaptive responses of the liver to severe inflammation or trauma that compromise normal hormone/xenobiotic metabolism (detoxification). 2 Isoxicam was notably less gastrotoxic than either piroxicam or tenoxicam, when given either orally or parenterally, at equipotent doses in rats.
摘要
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