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Dantrolene: evidence for effects on Na permeability properties of the nodal membrane.

作者信息

Schwarz J R, Spielmann R P

出版信息

Experientia. 1983 Jul 15;39(7):755-6. doi: 10.1007/BF01990310.

DOI:10.1007/BF01990310
PMID:6602716
Abstract

The effects of dantrolene on myelinated frog nerve fibers were studied in voltage clamp experiments. Dantrolene shifted the potential-dependent parameters describing Na+ permeability towards more negative membrane potentials. The findings are interpreted as a change in the negative surface charge of the membrane.

摘要

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本文引用的文献

1
The dual effect of membrane potential on sodium conductance in the giant axon of Loligo.枪乌贼巨大轴突中膜电位对钠电导的双重作用。
J Physiol. 1952 Apr;116(4):497-506. doi: 10.1113/jphysiol.1952.sp004719.
2
THE ACTION POTENTIAL IN THE MYELINATED NERVE FIBER OF XENOPUS LAEVIS AS COMPUTED ON THE BASIS OF VOLTAGE CLAMP DATA.基于电压钳数据计算得出的非洲爪蟾有髓神经纤维动作电位
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4
A three-state model for inactivation of sodium permeability.钠通透性失活的三态模型。
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5
A new voltage clamp method for Ranvier nodes.一种用于郎飞结的新型电压钳制方法。
Pflugers Arch. 1969;309(2):176-92. doi: 10.1007/BF00586967.
6
Calcium and lanthanum effects at the nodal membrane.钙和镧在结膜处的作用。
Pflugers Arch. 1974;350(1):25-39. doi: 10.1007/BF00586736.
7
Studies on the mechanism of action of dantrolene sodium. A skeletal muscle relaxant.丹曲林钠作用机制的研究。一种骨骼肌松弛剂。
Naunyn Schmiedebergs Arch Pharmacol. 1972;275(1):83-94. doi: 10.1007/BF00505069.
8
Excitation-contraction uncoupling in skeletal muscle by dantrolene sodium.丹曲林钠导致骨骼肌兴奋-收缩脱偶联。
Naunyn Schmiedebergs Arch Pharmacol. 1972;274(1):107-9. doi: 10.1007/BF00501011.
9
Calcium release from skeletal muscle sarcoplasmic reticulum: site of action of dantrolene sodium.骨骼肌肌浆网的钙释放：丹曲林钠的作用位点。
Science. 1976 Sep 17;193(4258):1130-1. doi: 10.1126/science.959824.
10
Inhibition of the intracellular release of calcium by Dantrolene in barnacle giant muscle fibres.丹曲林对藤壶巨大肌纤维细胞内钙释放的抑制作用。
J Physiol. 1977 Feb;265(2):565-85. doi: 10.1113/jphysiol.1977.sp011731.