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铟 - 111标记的自体血小板用于人体血管血栓定位

Indium-111-labeled autologous platelets for location of vascular thrombi in humans.

作者信息

Goodwin D A, Bushberg J T, Doherty P W, Lipton M J, Conley F K, Diamanti C I, Meares C F

出版信息

J Nucl Med. 1978 Jun;19(6):626-34.

PMID:660275
Abstract

Twenty-two patients suspected of having either venous or arterial thrombi were studied with In-111-labeled autologous platelets. Whole-body scans were performed 3, 24, and 48 hr following i.v. injection. Twelve patients studied with saline-washed platelets had unsatisfactory 15-min recovery and biologic half-time. When the labeling was carried out in plasma, these values compared favorably with normal values reported for Cr-51-labeled autologous platelets. Of ten patients studied using platelets labeled in plasma, three had normal scans, six had abnormal scans, and one had an equivocal scan. All six abnormal scans were confirmed with corresponding positive findings in either the venogram, arteriogram, or lung scan. J Nucl Med 19: 626-634, 1978.

摘要

对22名疑似患有静脉或动脉血栓的患者使用铟-111标记的自体血小板进行了研究。静脉注射后3小时、24小时和48小时进行全身扫描。对12名使用生理盐水洗涤血小板进行研究的患者,其15分钟恢复率和生物半衰期不理想。当在血浆中进行标记时,这些值与报道的铬-51标记自体血小板的正常值相比更有利。在使用血浆中标记的血小板进行研究的10名患者中,3名扫描结果正常,6名扫描结果异常,1名扫描结果不明确。所有6例异常扫描均在静脉造影、动脉造影或肺部扫描中得到相应的阳性结果证实。《核医学杂志》19: 626 - 634, 1978年。

相似文献

1
Indium-111-labeled autologous platelets for location of vascular thrombi in humans.铟 - 111标记的自体血小板用于人体血管血栓定位
J Nucl Med. 1978 Jun;19(6):626-34.
2
Scintigraphy with 111In-labeled autologous platelets in venous thromboembolism.静脉血栓栓塞症中使用¹¹¹铟标记自体血小板的闪烁显像术。
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4
[Diagnosis of thrombosis with indium-111 labeled thrombocytes].用铟-111标记血小板诊断血栓形成
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Scintigraphic detection of an arterial thrombus with In-111-labeled autologous platelets.用铟 - 111标记的自体血小板进行动脉血栓的闪烁显像检测。
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Indium-111 labelled platelets in diagnosis of leg-vein thrombosis: preliminary findings.铟-111标记血小板在诊断腿部静脉血栓形成中的应用:初步研究结果。
Br Med J. 1980 Jun 28;280(6231):1571-3. doi: 10.1136/bmj.280.6231.1571.
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[Detection of arterial thrombi using blood platelets labeled with indium-111].[使用铟 - 111标记的血小板检测动脉血栓]
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Scintigraphic detection of atherosclerotic lesions and venous thrombi in man by indium-111-labelled autologous platelets.利用铟 - 111标记的自体血小板对人体动脉粥样硬化病变和静脉血栓进行闪烁扫描检测。
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引用本文的文献

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Ophthalmodynamography and ophthalmodynamometry in neurological practice.
Doc Ophthalmol. 1980 May 30;49(1):97-153. doi: 10.1007/BF00175177.
2
Thrombosis: its role and prevention in cardiovascular events--Part I. Concepts of thrombogenesis and its prevention.血栓形成:其在心血管事件中的作用及预防——第一部分。血栓形成的概念及其预防。
West J Med. 1981 Mar;134(3):234-41.
3
Spleen function and platelet kinetics.脾脏功能与血小板动力学。
J Clin Pathol. 1981 Apr;34(4):377-80. doi: 10.1136/jcp.34.4.377.
4
[Platelet scintigraphy using indium-111].
Arch Psychiatr Nervenkr (1970). 1982;231(5):449-57. doi: 10.1007/BF00342724.
5
The use of 111In-labeled lymphocyte imaging to evaluate graft rejection following cardiac transplantation in dogs.
Eur J Nucl Med. 1982;7(4):162-5. doi: 10.1007/BF00443924.
6
Elution of 111Indium from reticuloendothelial cells.铟-111从网状内皮细胞中的洗脱
J Clin Pathol. 1982 May;35(5):507-9. doi: 10.1136/jcp.35.5.507.
7
Diagnosis of deep vein thrombosis using autologous indium-III-labelled platelets.使用自体铟-III标记血小板诊断深静脉血栓形成。
Br Med J (Clin Res Ed). 1981 Mar 28;282(6269):1020-2. doi: 10.1136/bmj.282.6269.1020.
8
Dual isotope scintigraphy in stroke patients.
Neuroradiology. 1984;26(2):113-7. doi: 10.1007/BF00339858.
9
Specific uptake of radioiodinated fragment E1 by venous thrombi in pigs.猪静脉血栓对放射性碘化片段E1的特异性摄取。
J Clin Invest. 1983 Dec;72(6):2007-13. doi: 10.1172/JCI111165.
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Detection of left atrial thrombi in man using indium-111 labelled autologous platelets.使用铟-111标记的自体血小板检测人体左心房血栓。
Br Heart J. 1984 Mar;51(3):298-305. doi: 10.1136/hrt.51.3.298.