Klonizakis I, Peters A M, Fitzpatrick M L, Kensett M J, Lewis S M, Lavender J P
J Clin Pathol. 1981 Apr;34(4):377-80. doi: 10.1136/jcp.34.4.377.
In patients suffering from various platelet abnormalities, quantitative scanning after injection of indium-111 (111In) labelled platelets showed three different patterns of platelet destruction and distribution. In patients with a normal platelet life span but with evidence of increased splenic pooling, the spleen tended to be the main site of destruction. In patients with a moderately reduced platelet life span, the distribution of destruction in the system and variable destruction in the marrow. However, because of its rapidity this destruction was difficult to quantify, and it was difficult in these cases to distinguish reliably between spleen pool, sequestration, and destruction. Destruction of platelets on the liver appeared to be unimportant in all three groups. 111In, because of its physical characteristics, is preferable to chromium-51 as a platelet label in the assessment of abnormal platelet kinetics.
在患有各种血小板异常的患者中，注射铟 - 111（¹¹¹In）标记的血小板后进行定量扫描显示出三种不同的血小板破坏和分布模式。在血小板寿命正常但有脾池增加证据的患者中，脾脏往往是主要的破坏部位。在血小板寿命中度缩短的患者中，破坏分布于全身且骨髓中有可变的破坏情况。然而，由于这种破坏速度很快，难以进行量化，并且在这些情况下很难可靠地区分脾池、滞留和破坏。在所有三组中，肝脏对血小板的破坏似乎并不重要。由于¹¹¹In的物理特性，在评估异常血小板动力学时，它比铬 - 51更适合作为血小板标记物。
