Lehmann M, Culig H, Taylor D M
Int J Radiat Biol Relat Stud Phys Chem Med. 1983 Jul;44(1):65-74. doi: 10.1080/09553008314550871.
An analysis of 239Pu-labelled protein complexes in serum and liver cytosol fractions prepared from rats injected intravenously with 239Pu-citrate indicated that among the possible metal-binding proteins, ferritin, transferrin and metallothionein, 239Pu was bound almost exclusively to transferrin. The method employed for the quantitative determination of 239Pu-transferrin was chromatography on immobilized rabbit anti-rat apo-transferrin. There was no evidence that transferrins from serum and liver cytosol are serologically different. The residual blood content of perfused and non-perfused liver was measured using 51Cr-labelled red blood cells and the amounts of blood-derived 239Pu and 239Pu-transferrin in the liver cytosol were calculated. The results are discussed with respect to the possible role of transferrin in the uptake of Pu into cells.
对静脉注射239Pu-柠檬酸盐的大鼠所制备的血清和肝细胞溶质部分中的239Pu标记蛋白复合物进行分析表明，在可能的金属结合蛋白铁蛋白、转铁蛋白和金属硫蛋白中，239Pu几乎只与转铁蛋白结合。用于定量测定239Pu-转铁蛋白的方法是在固定化兔抗大鼠脱铁转铁蛋白上进行色谱分析。没有证据表明血清和肝细胞溶质中的转铁蛋白在血清学上存在差异。使用51Cr标记的红细胞测量灌注和未灌注肝脏的残余血液含量，并计算肝细胞溶质中血液来源的239Pu和239Pu-转铁蛋白的量。讨论了这些结果与转铁蛋白在将钚摄取到细胞中的可能作用的关系。
