来自球形红假单胞菌ATCC 17023的无毒脂多糖。
Nontoxic lipopolysaccharide from Rhodopseudomonas sphaeroides ATCC 17023.
作者信息
Strittmatter W, Weckesser J, Salimath P V, Galanos C
出版信息
J Bacteriol. 1983 Jul;155(1):153-8. doi: 10.1128/jb.155.1.153-158.1983.
Abstract
Chemical analysis of the lipopolysaccharide from Rhodopseudomonas sphaeroides ATCC 17023, isolated by the phenol-chloroform-petroleum ether method, revealed the presence of glucuronic acid, 2-keto-3-deoxyoctonate, threonine, and phosphorus in the polysaccharide moiety. The lipid A component contained glucosamine, glucosamine phosphate, amide-bound 3-oxotetradecanoic acid and 3-hydroxytetradecanoic acid, and ester-bound 3-hydroxydecanoic acid and 7-tetradecenoic acid. Structural similarity of the lipid A from R. sphaeroides ATCC 17023 to enterobacterial lipid A is indicated by the existence of a serological cross-reaction occurring between the lipid A from R. sphaeroides ATCC 17023 and that from Salmonella minnesota R595. The lipopolysaccharide and lipid A of R. sphaeroides, however, were found to be neither toxic in mice nor pyrogenic in rabbits.
摘要
通过苯酚 - 氯仿 - 石油醚法分离得到的球形红假单胞菌ATCC 17023脂多糖的化学分析表明，多糖部分存在葡萄糖醛酸、2 - 酮 - 3 - 脱氧辛酸、苏氨酸和磷。脂质A成分含有葡糖胺、葡糖胺磷酸、酰胺结合的3 - 氧代十四烷酸和3 - 羟基十四烷酸，以及酯结合的3 - 羟基癸酸和7 - 十四碳烯酸。球形红假单胞菌ATCC 17023的脂质A与肠道细菌脂质A的结构相似性由球形红假单胞菌ATCC 17023的脂质A与明尼苏达沙门氏菌R595的脂质A之间发生的血清学交叉反应所表明。然而，发现球形红假单胞菌的脂多糖和脂质A对小鼠无毒，对兔子也无致热原性。
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