马血清中的一种类反应素抗体。II. 抗人IgE在马皮肤中诱导出类似反向皮肤过敏反应的应答。

A reagin-like antibody in horse serum. II. Anti-human IgE induced reversed cutaneous anaphylaxis-like responses in horse skin.

作者信息

Matthews A G, Imlah P, McPherson E A

出版信息

Vet Res Commun. 1983 Mar;6(2):111-22. doi: 10.1007/BF02214903.

Abstract

Fc specific anti-human IgE serum induced prolonged reversed cutaneous anaphylaxis (RCA)-like reactions in horse skin. Morphologically and histologically, these reactions resembled passively induced late cutaneous anaphylaxis responses in human skin, but differed from reversed passive Arthus responses induced in horse skin using anti-horse IgG serum. The induction of RCA-like responses in horse skin by anti-human IgE indicates shared Fc antigenic determinants on human IgE and a horse homocytotropic or reagin-like antibody.

摘要

Fc特异性抗人IgE血清在马皮肤中诱导出了类似皮肤过敏反应逆转（RCA）的长时间反应。从形态学和组织学上看，这些反应类似于人皮肤中被动诱导的迟发性皮肤过敏反应，但与使用抗马IgG血清在马皮肤中诱导的被动Arthus反应不同。抗人IgE在马皮肤中诱导出类似RCA的反应，这表明人IgE和一种马亲同种细胞性或反应素样抗体上存在共同的Fc抗原决定簇。