肾病综合征患儿T淋巴细胞亚群的评估
Evaluation of T lymphocyte subpopulations in children with nephrotic syndrome.
作者信息
Herrod H G, Stapleton F B, Trouy R L, Roy S
出版信息
Clin Exp Immunol. 1983 Jun;52(3):581-5.
Abstract
We have evaluated lymphocyte subsets both quantitatively and functionally in children with nephrotic syndrome. Ten children had minimal change nephrotic syndrome (MCNS), seven had focal segmental glomerular sclerosis (FSGS) and four had recovered from MCNS. Two patients with FSGS had decreased OKT4+ cells and a decreased T4/T8 ratio. Patients with active MCNS synthesized significantly less IgM in vitro than did normal subjects (P less than 0.005). In vitro IgG synthesis was significantly decreased in patients with active nephrotic syndrome whether it was due to MCNS or FSGS. Co-culture studies involving lymphocyte subsets suggested that both patients with decreased percentages of T4+ cells had decreased T helper cell activity as well. The results of this study support previous speculation about abnormal immune function in some patients with nephrotic syndrome.
摘要
我们对肾病综合征患儿的淋巴细胞亚群进行了定量和功能评估。10名儿童患有微小病变型肾病综合征（MCNS），7名患有局灶节段性肾小球硬化（FSGS），4名已从MCNS康复。两名FSGS患者的OKT4 +细胞减少，T4/T8比值降低。活动性MCNS患者体外合成的IgM明显少于正常受试者（P小于0.005）。无论是由MCNS还是FSGS引起的活动性肾病综合征患者，其体外IgG合成均显著降低。涉及淋巴细胞亚群的共培养研究表明，T4 +细胞百分比降低的两名患者的辅助性T细胞活性也降低。本研究结果支持了先前关于某些肾病综合征患者免疫功能异常的推测。
相似文献
1
Evaluation of T lymphocyte subpopulations in children with nephrotic syndrome.肾病综合征患儿T淋巴细胞亚群的评估
Clin Exp Immunol. 1983 Jun;52(3):581-5.
2
T cell subsets in glomerulonephritis.肾小球肾炎中的T细胞亚群。
Int J Pediatr Nephrol. 1986 Apr-Jun;7(2):63-8.
3
Pathophysiology of minimal change nephrotic syndrome and focal segmental glomerulosclerosis.微小病变型肾病综合征和局灶节段性肾小球硬化症的病理生理学
Nephrology (Carlton). 2007 Dec;12 Suppl 3:S11-4. doi: 10.1111/j.1440-1797.2007.00875.x.
4
In vitro B-lymphocyte switch disturbance from IgM into IgG in IgM mesangial nephropathy.IgM系膜肾病中体外B淋巴细胞从IgM向IgG的转换紊乱。
Pediatr Nephrol. 1989 Jul;3(3):254-8. doi: 10.1007/BF00858525.
5
Enhanced suppressor T cell activity resulting in increased IgM and decreased IgG productions in children with minimal change nephrotic syndrome.微小病变型肾病综合征患儿抑制性T细胞活性增强，导致IgM产生增加，IgG产生减少。
Int J Pediatr Nephrol. 1987 Apr-Jun;8(2):75-80.
6
Altered expression of B lymphocyte surface immunoglobulins in minimal change nephrotic syndrome and focal glomerulosclerosis.
Nephron. 1984;37(4):224-8. doi: 10.1159/000183253.
7
Basophil sensitisation in idiopathic nephrotic syndrome.特发性肾病综合征中的嗜碱性粒细胞致敏
Lancet. 1982 Feb 13;1(8268):358-61. doi: 10.1016/s0140-6736(82)91391-5.
8
Minimal change glomerulonephritis and focal glomerulosclerosis markers and 'in vitro' activity of peripheral blood mononuclear cell.微小病变型肾小球肾炎和局灶节段性肾小球硬化的标志物以及外周血单个核细胞的“体外”活性
Proc Eur Dial Transplant Assoc. 1983;19:673-8.
9
[Idiopathic nephrotic syndrome].[特发性肾病综合征]
Vutr Boles. 1984;23(4):14-21.
10
Incidence & significance of IgM mesangial deposits in relapsing idiopathic nephrotic syndrome of childhood.儿童复发性特发性肾病综合征中IgM系膜沉积物的发生率及意义
Indian J Med Res. 1987 Jul;86:53-60.
引用本文的文献
1
Autoimmunity in Focal Segmental Glomerulosclerosis: A Long-Standing Yet Elusive Association.局灶节段性肾小球硬化中的自身免疫：一种长期存在但难以捉摸的关联。
Front Med (Lausanne). 2020 Nov 20;7:604961. doi: 10.3389/fmed.2020.604961. eCollection 2020.
2
Immunologic Changes Implicated in the Pathogenesis of Focal Segmental Glomerulosclerosis.与局灶节段性肾小球硬化发病机制相关的免疫变化
Biomed Res Int. 2016;2016:2150451. doi: 10.1155/2016/2150451. Epub 2016 Feb 17.
3
Increased Migratory and Activation Cell Markers of Peripheral Blood Lymphocytes in an Experimental Model of Nephrotic Syndrome.肾病综合征实验模型中外周血淋巴细胞迁移和活化细胞标志物增加
Mediators Inflamm. 2015;2015:209764. doi: 10.1155/2015/209764. Epub 2015 May 7.
4
The role of the immune system in idiopathic nephrotic syndrome: a review of clinical and experimental studies.免疫系统在特发性肾病综合征中的作用：临床与实验研究综述。
Inflamm Res. 2014 Jan;63(1):1-12. doi: 10.1007/s00011-013-0672-6.
5
CD19 + CD23+ B cells, CD4 + CD25+ T cells, E-selectin and interleukin-12 levels in children with steroid sensitive nephrotic syndrome.激素敏感型肾病综合征患儿外周血 CD19+CD23+B 细胞、CD4+CD25+T 细胞、E-选择素及白介素-12 水平的变化
Ital J Pediatr. 2013 Jul 6;39:42. doi: 10.1186/1824-7288-39-42.
6
T cell CD3 receptor zeta (TCRzeta)-chain expression in children with idiopathic nephrotic syndrome.特发性肾病综合征患儿的T细胞CD3受体ζ链（TCRζ链）表达
Pediatr Nephrol. 2009 Apr;24(4):769-73. doi: 10.1007/s00467-008-1061-1. Epub 2008 Dec 10.
7
Lymphocyte subpopulations, interleukin-2 and interleukin-2 receptor expression in childhood nephrotic syndrome.儿童肾病综合征中的淋巴细胞亚群、白细胞介素-2及白细胞介素-2受体表达
Pediatr Nephrol. 1994 Apr;8(2):135-9. doi: 10.1007/BF00865458.
8
T-cell subsets, interleukin-2 receptor expression and production of interleukin-2 in minimal change nephrotic syndrome.微小病变型肾病中的T细胞亚群、白细胞介素-2受体表达及白细胞介素-2产生
Pediatr Nephrol. 1994 Dec;8(6):649-52. doi: 10.1007/BF00869075.
9
Impaired immunoglobulin G production in minimal change nephrotic syndrome in adults.成人微小病变型肾病中免疫球蛋白G产生受损。
Clin Exp Immunol. 1987 Oct;70(1):110-5.
10
The immune system in minimal change nephrotic syndrome.微小病变型肾病综合征中的免疫系统。
Pediatr Nephrol. 1989 Jan;3(1):101-10. doi: 10.1007/BF00859637.
本文引用的文献
1
Studies on the metabolism of plasma proteins in the nephrotic syndrome. I. Albumin, gamma-globulin and iron-binding globulin.肾病综合征血浆蛋白代谢的研究。I. 白蛋白、γ球蛋白与铁结合球蛋白。
J Clin Invest. 1956 Jan;35(1):44-56. doi: 10.1172/JCI103251.
2
T-cell dysfunction in minimal-change nephrotic syndrome of childhood.儿童微小病变型肾病综合征中的T细胞功能障碍。
Am J Dis Child. 1982 Aug;136(8):713-7. doi: 10.1001/archpedi.1982.03970440057016.
3
Inhibitory factors of lymphocyte transformation in sera from patients with minimal change nephrotic syndrome.微小病变型肾病综合征患者血清中淋巴细胞转化的抑制因子
Clin Nephrol. 1980 Jun;13(6):271-6.
4
Long-term impairment of suppressor-cell function by cyclophosphamide in minimal-change nephropathy and its association with therapeutic response.
Lancet. 1981 Jan 31;1(8214):235-8. doi: 10.1016/s0140-6736(81)92084-5.
5
Immunochemical semiquantitative estimation of gamma-M- and gamma-A-immunoglobulins in healthy and diseased children. 2. Immunoglobulin levels in nephrotic syndrome, exudative enteropathy, acute leukemia, and malignant tumors.健康儿童与患病儿童γ-M和γ-A免疫球蛋白的免疫化学半定量评估。2. 肾病综合征、渗出性肠病、急性白血病及恶性肿瘤中的免疫球蛋白水平。
Acta Paediatr Jpn. 1965 Jun;7(13):13-22. doi: 10.1111/j.1442-200x.1965.tb01169.x.
6
Pathogenesis of lipoid nephrosis: a disorder of T-cell function.脂性肾病的发病机制：一种T细胞功能紊乱疾病。
Lancet. 1974 Sep 7;2(7880):556-60. doi: 10.1016/s0140-6736(74)91880-7.
7
Letter: Serum immunoglobulins in idiopathic minimal-change nephrotic syndrome.
N Engl J Med. 1976 Jan 1;294(1):50-1. doi: 10.1056/NEJM197601012940117.
8
Serum immunoglobulins in the nephrotic syndrome. A possible cause of minimal-change nephrotic syndrome.
N Engl J Med. 1975 Jul 3;293(1):8-12. doi: 10.1056/NEJM197507032930103.
9
A serum inhibitor of blastogenesis in idiopathic nephrotic syndrome transferred by lymphocytes.由淋巴细胞传递的特发性肾病综合征中一种抑制母细胞生成的血清抑制剂。
Clin Immunol Immunopathol. 1979 Jan;12(1):62-71. doi: 10.1016/0090-1229(79)90111-9.
10
Use of a human plaque-forming cell assay to study peripheral blood bursa-equivalent cell activation and excessive suppressor cell activity in humoral immunodeficiency.利用人空斑形成细胞试验研究体液免疫缺陷中外周血法氏囊等效细胞激活及抑制细胞活性过度的情况。
J Clin Invest. 1979 May;63(5):868-76. doi: 10.1172/JCI109386.
Zotero 插件