肾病综合征患儿T淋巴细胞亚群的评估
Evaluation of T lymphocyte subpopulations in children with nephrotic syndrome.
作者信息
Herrod H G, Stapleton F B, Trouy R L, Roy S
出版信息
Clin Exp Immunol. 1983 Jun;52(3):581-5.
Abstract
We have evaluated lymphocyte subsets both quantitatively and functionally in children with nephrotic syndrome. Ten children had minimal change nephrotic syndrome (MCNS), seven had focal segmental glomerular sclerosis (FSGS) and four had recovered from MCNS. Two patients with FSGS had decreased OKT4+ cells and a decreased T4/T8 ratio. Patients with active MCNS synthesized significantly less IgM in vitro than did normal subjects (P less than 0.005). In vitro IgG synthesis was significantly decreased in patients with active nephrotic syndrome whether it was due to MCNS or FSGS. Co-culture studies involving lymphocyte subsets suggested that both patients with decreased percentages of T4+ cells had decreased T helper cell activity as well. The results of this study support previous speculation about abnormal immune function in some patients with nephrotic syndrome.
摘要
我们对肾病综合征患儿的淋巴细胞亚群进行了定量和功能评估。10名儿童患有微小病变型肾病综合征（MCNS），7名患有局灶节段性肾小球硬化（FSGS），4名已从MCNS康复。两名FSGS患者的OKT4 +细胞减少，T4/T8比值降低。活动性MCNS患者体外合成的IgM明显少于正常受试者（P小于0.005）。无论是由MCNS还是FSGS引起的活动性肾病综合征患者，其体外IgG合成均显著降低。涉及淋巴细胞亚群的共培养研究表明，T4 +细胞百分比降低的两名患者的辅助性T细胞活性也降低。本研究结果支持了先前关于某些肾病综合征患者免疫功能异常的推测。
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