Neilan B A, Vonderheid E C, O'Neill K J
J Invest Dermatol. 1983 Aug;81(2):176-8. doi: 10.1111/1523-1747.ep12543616.
Natural cell-mediated cytotoxicity was studied in 24 patients with cutaneous T-cell lymphomas and in 18 age- and sex-matched controls studied concomitantly. Percent cytotoxicity was determined by 4-h 51Cr release assay using K562 targets at effector to target ratios of 100:1, 50:1, and 25:1. Mean percent cytotoxicity was significantly lower in patients than in controls at an effector to target cell ration of 100:1. Likewise, decreased cytotoxicity was found at effector to target ratios of 50:1 and 25:1, although this difference was not significant. When natural killer activity was analyzed separately for males and females, cytotoxicity was lower in both, although the decrease was significant only for male patients. Impairment of natural killer activity did not correlate with blood zinc levels, but appeared to correlate with stage of disease.
对24例皮肤T细胞淋巴瘤患者以及18例年龄和性别匹配的对照者同时进行了自然细胞介导的细胞毒性研究。通过4小时51Cr释放试验，以效应细胞与靶细胞比例为100:1、50:1和25:1，使用K562靶细胞来测定细胞毒性百分比。在效应细胞与靶细胞比例为100:1时，患者的平均细胞毒性百分比显著低于对照者。同样，在效应细胞与靶细胞比例为50:1和25:1时，也发现细胞毒性降低，尽管这种差异不显著。当分别分析男性和女性的自然杀伤活性时，两者的细胞毒性均较低，不过仅男性患者的降低具有显著性。自然杀伤活性的损害与血锌水平无关，但似乎与疾病分期相关。
