Miller R L, Verma P S, Adams R G
J Natl Med Assoc. 1983 Jun;75(6):551-6.
Eight patients with sickle cell anemia (SS hemoglobin) were found to have decreased plasma levels of prekallikrein compared to normal control subjects or patients with other types of anemia. The prekallikrein levels in the patients with sickle cell anemia were found to decrease further during a sickle cell crisis. These results suggest that components of the kallikrein-kinin system are profoundly affected in patients with sickle cell anemia, and during crises may play a role in the clinical presentation of patients.
与正常对照受试者或其他类型贫血患者相比，发现8例镰状细胞贫血（SS血红蛋白）患者的血浆前激肽释放酶水平降低。镰状细胞贫血患者的前激肽释放酶水平在镰状细胞危象期间进一步下降。这些结果表明，激肽释放酶-激肽系统的成分在镰状细胞贫血患者中受到严重影响，并且在危象期间可能在患者的临床表现中起作用。
