在人淋巴母细胞系的悬浮培养中，促肿瘤佛波酯对细胞增殖的刺激作用以及某些肿瘤促进抑制剂的抑制作用。
Stimulation of cell proliferation by tumor-promoting phorbol esters and inhibition by some inhibitors of tumor promotion in suspension cultures of a human lymphoblastoid cell line.
作者信息
Honma Y, Kasukabe T, Hozumi M, Nakazawa S
出版信息
J Cancer Res Clin Oncol. 1983;106(1):81-3. doi: 10.1007/BF00399904.
Abstract
A human lymphoblastoid cell line, SCC-1, was established from the bone marrow of a patient with acute nonlymphocytic leukemia. 12-O-Tetradecanoylphorbol-13-acetate (TPA) enhanced cell proliferation of SCC-1 cells in suspension culture. A positive correlation was found between the tumor-promoting activities of several plant diterpenes and their enhancing effects on the growth of SCC-1 cells. Various compounds that inhibit tumor promotion were tested for their capacity to inhibit cell proliferation at a physiological concentration. These compounds were not cytotoxic but cytostatic even at high concentration.
摘要
从一名急性非淋巴细胞白血病患者的骨髓中建立了人淋巴母细胞系SCC-1。12-O-十四烷酰佛波醇-13-乙酸酯（TPA）增强了悬浮培养的SCC-1细胞的增殖。发现几种植物二萜的促肿瘤活性与其对SCC-1细胞生长的增强作用之间存在正相关。测试了各种抑制肿瘤促进的化合物在生理浓度下抑制细胞增殖的能力。这些化合物即使在高浓度下也没有细胞毒性，而是具有细胞生长抑制作用。
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Stimulation of cell proliferation by tumor-promoting phorbol esters and inhibition by some inhibitors of tumor promotion in suspension cultures of a human lymphoblastoid cell line.在人淋巴母细胞系的悬浮培养中，促肿瘤佛波酯对细胞增殖的刺激作用以及某些肿瘤促进抑制剂的抑制作用。
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本文引用的文献
1
Phorbol ester-induced differentiation of chronic lymphocytic leukaemia cells.佛波酯诱导慢性淋巴细胞白血病细胞分化
Nature. 1980 Nov 13;288(5787):176-8. doi: 10.1038/288176a0.
2
3
Tumor promoter phorbol myristic acetate stimulates immunoglobulin secretion correlated with growth cessation in human B lymphocyte cell lines.肿瘤启动子佛波醇肉豆蔻酸酯刺激人B淋巴细胞系中与生长停滞相关的免疫球蛋白分泌。
J Clin Invest. 1981 Oct;68(4):1093-6. doi: 10.1172/jci110332.
4
Human myelogenous leukemia: enhanced clonal proliferation in the presence of phorbol diesters.人类髓性白血病：在佛波酯存在下克隆增殖增强。
Blood. 1981 Feb;57(2):256-60.
5
Phorbol esters induce differentiation in human malignant T lymphoblasts.佛波酯可诱导人恶性T淋巴母细胞分化。
Proc Natl Acad Sci U S A. 1980 May;77(5):2964-8. doi: 10.1073/pnas.77.5.2964.
6
7
Polyinosinic-polycytidylic acid inhibits chemically induced tumorigenesis in mouse skin.聚肌苷酸-聚胞苷酸抑制化学诱导的小鼠皮肤肿瘤发生。
Science. 1970 Jan 9;167(3915):205-7. doi: 10.1126/science.167.3915.205.
8
Inhibitory effect of vitamin A on carcinogenesis.维生素A对致癌作用的抑制效应。
J Natl Cancer Inst. 1971 Sep;47(3):667-73.
9
The inhibition of croton oil-promoted mouse skin tumorigenesis by steroid hormones.类固醇激素对巴豆油促进的小鼠皮肤肿瘤发生的抑制作用。
Cancer Res. 1972 Mar;32(3):450-4.
10
Chemical carcinogenesis in mice inhibited by interferon.
Nat New Biol. 1972 Sep 6;239(88):31-2. doi: 10.1038/newbio239031a0.
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