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用针对小鼠B细胞肿瘤细胞表面IgM独特型决定簇的抗体和F(ab')2片段对该肿瘤进行免疫治疗。

Immunotherapy of a murine B cell tumor with antibodies and F(ab')2 fragments against idiotypic determinants of its cell surface IgM.

作者信息

Perek Y, Hurwitz E, Burowski D, Haimovich J

出版信息

J Immunol. 1983 Sep;131(3):1600-3.

PMID:6604103
Abstract

Anti-idiotype antibodies against the IgM of the 38C-13 murine B lymphocyte cell line and F(ab')2 fragments derived from them were checked for their therapeutic effect against the killing of mice by 38C-13 cells. Both intact molecules and the F(ab')2 fragments were effective in delaying or preventing the killing of mice by 38C-13 tumors when used in large amounts and by the appropriate routes.

摘要

检测了针对38C - 13小鼠B淋巴细胞系IgM的抗独特型抗体及其衍生的F(ab')2片段对38C - 13细胞杀死小鼠的治疗效果。当大量且通过适当途径使用时，完整分子和F(ab')2片段均可有效延迟或防止38C - 13肿瘤对小鼠的杀伤。

相似文献

1
Immunotherapy of a murine B cell tumor with antibodies and F(ab')2 fragments against idiotypic determinants of its cell surface IgM.用针对小鼠B细胞肿瘤细胞表面IgM独特型决定簇的抗体和F(ab')2片段对该肿瘤进行免疫治疗。
J Immunol. 1983 Sep;131(3):1600-3.
2
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Anti-idiotypic antibodies recognizing stable epitopes limit the emergence of idiotype variants in a murine B cell lymphoma.识别稳定表位的抗独特型抗体限制了小鼠B细胞淋巴瘤中独特型变体的出现。
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Expression of immunoglobulin-cross-reactive molecules by neoplastic human T cells. I. Surface detection and isolation of molecules reactive with chicken anti-F(ab')2, anti-alpha and anti-mu antibodies.人肿瘤性T细胞免疫球蛋白交叉反应分子的表达。I. 与鸡抗F(ab')2、抗α和抗μ抗体反应的分子的表面检测与分离
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Idiotypic interactions between normal human polyspecific IgG and natural IgM antibodies.正常人多特异性IgG与天然IgM抗体之间的独特型相互作用。
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引用本文的文献

1
Syngeneic antiidiotypic immune responses to a B cell lymphoma. Comparison between heavy chain hypervariable region peptides and intact Ig as immunogens.针对B细胞淋巴瘤的同基因抗独特型免疫反应。重链高变区肽段与完整免疫球蛋白作为免疫原的比较。
J Exp Med. 1985 Jul 1;162(1):19-34. doi: 10.1084/jem.162.1.19.
2
Selective cytotoxicity against tumor cells by cisplatin complexed to antitumor antibodies via carboxymethyl dextran.通过羧甲基葡聚糖与抗肿瘤抗体复合的顺铂对肿瘤细胞的选择性细胞毒性。
Cancer Immunol Immunother. 1987;25(3):225-30. doi: 10.1007/BF00199151.
3
Suppression of in vivo tumor formation induced by simian virus 40-transformed cells in mice receiving antiidiotypic antibodies.
在接受抗独特型抗体的小鼠中，猿猴病毒40转化细胞诱导的体内肿瘤形成受到抑制。
J Exp Med. 1985 Jun 1;161(6):1432-49. doi: 10.1084/jem.161.6.1432.
4
Immunotherapy of B lymphoma by anti-idiotype antibodies: characterization of variant tumour cells appearing a long time after the initial tumour inoculation.抗独特型抗体对B淋巴瘤的免疫治疗：初次接种肿瘤后长时间出现的变异肿瘤细胞的特征
Cancer Immunol Immunother. 1991;34(1):43-8. doi: 10.1007/BF01741323.