McDowell A E, Pardue H L
J Pharm Sci. 1978 Jun;67(6):822-6. doi: 10.1002/jps.2600670625.
A vidicon spectrometer, useful for absorption spectrophotometry over the 210-800-nm spectral region and capable of scanning a portion of this region at repetition rates of 250 scans/sec, was applied for the simultaneous determination of multicomponent drug formulations without a separation. Results are reported for two drug preparations containing two and four active components. The average of ratios of determined to expected values for the six active components contained in both formulations was 99.2% based on the specified tablet contents. Relative standard errors for the analyses were less than 3%. Other potential applications of the vidicon spectrometer are discussed briefly.
一种光导摄像管光谱仪，适用于210 - 800纳米光谱区域的吸收分光光度法，能够以250次扫描/秒的重复速率扫描该区域的一部分，被用于在无需分离的情况下同时测定多组分药物制剂。报告了两种分别含有两种和四种活性成分的药物制剂的结果。基于指定的片剂含量，两种制剂中所含六种活性成分的测定值与预期值之比的平均值为99.2%。分析的相对标准误差小于3%。简要讨论了光导摄像管光谱仪的其他潜在应用。
