Raaphorst G P, Azzam E I, Borsa J, Einspenner M
Int J Radiat Biol Relat Stud Phys Chem Med. 1983 Sep;44(3):275-83. doi: 10.1080/09553008314551151.
The survival response of Friend erythroleukemia cells (a differentiating cell system) to heat and radiation has been examined. The Friend erythroleukemia cells (FELC) were more heat and radiation sensitive than V79 cells, and the heat and radiation survival curves possessed shoulders, showing the ability of the cells to accumulate sublethal damage. Thermal tolerance was expressed after prolonged heating at 41.0-42.0 degrees C. Thermal radiosensitization by heating at 42.0 or 45.0 degrees C was greatest for simultaneous heat and radiation treatments, and recovery occurred when the cells were incubated at 37 degrees C between the heat and radiation or radiation and heat treatments. Arrhenius analysis of the FELC heat survival data showed that the curve for thermal inactivation possessed a break at about 43.0 degrees C and that the thermal inactivation energies above and below the break point were comparable to those for V79 cells and other cell lines reported in the literature.
已对弗氏红白血病细胞（一种分化细胞系统）对热和辐射的存活反应进行了研究。弗氏红白血病细胞（FELC）比V79细胞对热和辐射更敏感，并且热和辐射存活曲线具有肩区，表明细胞具有积累亚致死损伤的能力。在41.0 - 42.0℃长时间加热后表现出热耐受性。对于同时进行热和辐射处理，在42.0或45.0℃加热时热放射增敏作用最大，并且当细胞在热和辐射或辐射和热处理之间于37℃孵育时会发生恢复。对FELC热存活数据的阿累尼乌斯分析表明，热失活曲线在约43.0℃处有一个断点，并且断点上下的热失活能量与文献中报道的V79细胞和其他细胞系的热失活能量相当。
