分化中的小鼠红白血病细胞系中的热疗：II. 热对辐射诱导血红素的影响。

Hyperthermia in a differentiating murine erythroleukaemia cell line: II. Effect of heat on haem induction by radiation.

作者信息

Raaphorst G P, Azzam E I, Borsa J, Einspenner M, Vadasz J

出版信息

Int J Radiat Biol Relat Stud Phys Chem Med. 1983 Oct;44(4):343-52. doi: 10.1080/09553008314551281.

Abstract

Friend erythroleukaemia cells (FELC) were induced to a haem-producing state by X-rays. The percentage of haem positive cells was maximum for doses between 10 and 15 Gy. Heat treatment at 42.0 degrees C or 45.0 degrees C during or after irradiation inhibited haem induction whereas heating before irradiation enhanced it. Incubation at 37 degrees C between heating and irradiation resulted in a decline in induction levels, indicating repair of heat damage that interacts with X-ray damage. Incubation at 37 degrees C between irradiation and heating did not result in changed haem induction levels, indicating a lack of repair of radiation damage that could interact with subsequent damage produced by heating.

摘要

Friend红白血病细胞（FELC）通过X射线诱导进入产血状态。对于10至15 Gy之间的剂量，产血阳性细胞的百分比最高。在照射期间或照射后于42.0℃或45.0℃进行热处理会抑制产血诱导，而在照射前加热则会增强产血诱导。在加热和照射之间于37℃孵育导致诱导水平下降，表明热损伤的修复与X射线损伤相互作用。在照射和加热之间于37℃孵育并未导致产血诱导水平改变，表明不存在可与加热产生的后续损伤相互作用的辐射损伤修复。