Selvaggi L, Lucivero G, Iannone A, dell'Osso A, Loverro G, Antonaci S, Bonomo L, Bettocchi S
J Perinat Med. 1983;11(4):213-7. doi: 10.1515/jpme.1983.11.4.213.
We have examined the mononuclear cell (MC) subpopulations of 5 pregnant women: Three of them had a previous history of IUGR, whereas two were primiparae and presented IUGR at the term of gestation. IUGR was confirmed after delivery in three women. The analysis of MC subsets was performed by rosetting and immunofluorescence techniques; both heterologous antisera specific for human immunoglobulins and monoclonal antibodies specific for T cell antigens and for M1 and Ia-like antigens were used. The three patients with IUGR confirmed at birth presented numbers of circulating lymphoid cells positive for cytoplasmic IgM, IgG and IgA and with morphologic features of plasmablasts or plasma cells at least tenfold higher than in normal pregnant women at the term of gestation. Our data suggest that chronic activation of the lymphoid system occurs in pregnant women with IUGR. Maternal abnormal reactivity to fetal antigens or to undiagnosed chronic infections may be likely explanations for this phenomenon. Further studies are clearly needed to clarify the relationship between B-lymphocyte activation and pregnancy and to examine the hypothesis of an altered balance of the immunoregulatory T lymphocyte subsets in patients with IUGR.
我们检查了5名孕妇的单核细胞（MC）亚群：其中3名有宫内生长受限（IUGR）病史，而另外2名是初产妇，在妊娠足月时出现IUGR。3名女性在分娩后确诊为IUGR。通过玫瑰花结形成和免疫荧光技术对MC亚群进行分析；使用了针对人免疫球蛋白的异源抗血清以及针对T细胞抗原、M1和Ia样抗原的单克隆抗体。出生时确诊为IUGR的3名患者中，循环淋巴细胞中细胞质IgM、IgG和IgA呈阳性且具有成浆细胞或浆细胞形态特征的数量至少比妊娠足月的正常孕妇高10倍。我们的数据表明，IUGR孕妇的淋巴系统存在慢性激活。母体对胎儿抗原或未确诊的慢性感染的异常反应可能是这一现象的合理解释。显然需要进一步研究来阐明B淋巴细胞激活与妊娠之间的关系，并检验IUGR患者免疫调节性T淋巴细胞亚群平衡改变的假说。
