宫内生长受限妊娠夫妇的混合淋巴细胞反应受到抑制。
Suppressed mixed lymphocyte reaction in couples with intrauterine growth retardation pregnancies.
作者信息
Tsushima R, Fujii T, Nakamura A, Okai T, Juji T, Taketani Y
机构信息
Department of Obstetrics and Gynecology, School of Medicine, University of Tokyo, Japan.
出版信息
Int J Gynaecol Obstet. 1995 Jan;48(1):37-42. doi: 10.1016/0020-7292(94)02259-3.
OBJECTIVE
The objective of this study was to gain insight into the pathogenesis of intrauterine growth retardation (IUGR).
METHOD
Immune reactivity against paternal MHC class-II antigens was determined in 18 women with IUGR pregnancies and 18 normal pregnant women, employing one-way mixed lymphocyte reaction (MLR).
RESULTS
One-way MLR between the women with IUGR pregnancies and their husbands was significantly suppressed compared with that between the women with IUGR pregnancies and males unrelated to them. However the MLR of normal pregnant women was essentially similar regardless of whether stimulating cells were obtained from their husbands or not. The degree of HLA class-II antigen shared by IUGR couples was not related to the degree of specific suppression of MLR towards the husbands.
CONCLUSION
IUGR may be associated with specifically suppressed patients' MLR towards their husbands, which may provide insight into the underlying pathophysiology of IUGR.
目的
本研究的目的是深入了解宫内生长受限（IUGR）的发病机制。
方法
采用单向混合淋巴细胞反应（MLR），对18例IUGR妊娠妇女和18例正常孕妇进行针对父本MHC-II类抗原的免疫反应性测定。
结果
与IUGR妊娠妇女和与其无关男性之间的单向MLR相比，IUGR妊娠妇女与其丈夫之间的单向MLR受到显著抑制。然而，正常孕妇的MLR基本相似无论刺激细胞是否取自其丈夫。IUGR夫妇共有的HLA-II类抗原程度与对丈夫的MLR特异性抑制程度无关。
结论
IUGR可能与患者对其丈夫的MLR特异性抑制有关，这可能有助于深入了解IUGR的潜在病理生理学。
Zotero 插件