Ono M, Tanaka N, Orita K
Acta Med Okayama. 1983 Aug;37(4):367-76. doi: 10.18926/AMO/32396.
Antibody-dependent cellular cytotoxicity (ADCC) increased with the development of tumors in C3H/He mice bearing spontaneous breast cancer or the syngeneic hepatoma MH-134 and in C57BL/6 mice bearing the syngeneic Lewis lung carcinoma 3LL. This cytotoxicity decreased after treatment with guinea pig, monoclonal IgM anti-Thy 1.2 serum and complement to the non-cancer level thus indicating that the increased ADCC in mice with cancer seems mainly attributable to cells with the Thy 1 antigen. On the other hand, NK activity decreased greatly when mice had tumors. Treatment with monoclonal IgM anti-Thy 1.2 serum and complement showed no significant influence on the natural killer (NK) activity of spleen cells of mice bearing MH-134 cancer, but in the 3LL-bearing mice the activity decreased significantly.
在患有自发性乳腺癌的C3H/He小鼠或同基因肝癌MH-134以及患有同基因Lewis肺癌3LL的C57BL/6小鼠中，抗体依赖性细胞毒性（ADCC）随着肿瘤的发展而增加。在用豚鼠单克隆IgM抗Thy 1.2血清和补体处理后，这种细胞毒性降低至非癌水平，这表明癌症小鼠中ADCC的增加似乎主要归因于具有Thy 1抗原的细胞。另一方面，当小鼠患有肿瘤时，NK活性大大降低。用单克隆IgM抗Thy 1.2血清和补体处理对患有MH-134癌的小鼠脾细胞的自然杀伤（NK）活性没有显著影响，但在患有3LL的小鼠中，该活性显著降低。
