Runge V M, Clanton J A, Smith F W, Hutchison J, Mallard J, Partain C L, James A E
AJR Am J Roentgenol. 1983 Nov;141(5):943-8. doi: 10.2214/ajr.141.5.943.
The tissue levels of paramagnetic ions are an important factor in the determination of T1 values as observed by nuclear magnetic resonance (NMR) imaging. The increased levels of iron present in human disease states such as hemochromatosis lead to decreased T1 values. The mean liver T1 of three patients with iron storage disease was determined to be 130 msec, significantly different from the value of 154 msec, the mean for 14 normal controls. Whether NMR will be able to detect the increased copper levels in liver and brain in Wilson disease remains for further clinical trials to evaluate. NMR imaging, however, does serve as a noninvasive method for the diagnosis of states of iron overload and as a technique to follow progression of disease or response to medical therapy.
顺磁性离子的组织水平是通过核磁共振（NMR）成像观察确定T1值的一个重要因素。在诸如血色素沉着症等人类疾病状态下，铁水平升高会导致T1值降低。三名铁储存疾病患者的肝脏平均T1值被确定为130毫秒，与14名正常对照者的平均值154毫秒有显著差异。核磁共振能否检测出威尔逊病患者肝脏和大脑中升高的铜水平仍有待进一步的临床试验评估。然而，核磁共振成像确实可作为一种非侵入性方法用于诊断铁过载状态，以及作为一种跟踪疾病进展或药物治疗反应的技术。
