Pichichero M E, Insel R A
J Allergy Clin Immunol. 1983 Nov;72(5 Pt 1):481-6. doi: 10.1016/0091-6749(83)90585-7.
The simultaneous serum and mucosal antibody response to parenteral vaccination with the Haemophilus influenzae type b (Hib) polysaccharide capsule (PRP) was evaluated in a group of 10 children and nine adults. All subjects responded to parenteral vaccination with an increase in serum anticapsular antibody. The children's preimmunization anti-PRP antibody level (mean = 0.04 microgram/ml) and 3 wk postimmunization level (mean = 19.3 micrograms/ml) were lower than the adults' (preimmunization mean = 1.5 microgram/ml; postimmunization mean = 81.2 micrograms/ml). Eight of 10 children and seven of nine adults also developed a rise in antibody in nasal secretions. The children's mean nasal preimmunization level was 0.74 microgram/mg IgA and mean postimmunization level was 5.0 micrograms/mg IgA. The adults' mean nasal preimmunization level was 0.98 microgram/mg IgA and mean postimmunization level was 3.0 micrograms/mg IgA. Salivary antibody responses generally followed the pattern of nasal antibody responses. These data suggest that parenteral administration with the Hib capsular polysaccharide can produce a mucosal antibody response. Furthermore, although serum antibody responses to PRP vaccination are greater in adults than in children, mucosal antibody responses are comparable.
对一组10名儿童和9名成人进行了评估，以观察其对注射b型流感嗜血杆菌（Hib）多糖胶囊（PRP）的同时血清和黏膜抗体反应。所有受试者对注射疫苗均有反应，血清抗荚膜抗体增加。儿童免疫前抗PRP抗体水平（平均 = 0.04微克/毫升）和免疫后3周水平（平均 = 19.3微克/毫升）低于成人（免疫前平均 = 1.5微克/毫升；免疫后平均 = 81.2微克/毫升）。10名儿童中的8名和9名成人中的7名鼻分泌物中的抗体也出现升高。儿童鼻免疫前平均水平为0.74微克/毫克IgA，免疫后平均水平为5.0微克/毫克IgA。成人鼻免疫前平均水平为0.98微克/毫克IgA，免疫后平均水平为3.0微克/毫克IgA。唾液抗体反应通常遵循鼻抗体反应的模式。这些数据表明，注射Hib荚膜多糖可产生黏膜抗体反应。此外，虽然成人对PRP疫苗接种的血清抗体反应比儿童更强，但黏膜抗体反应相当。
