天然前列腺素和前列腺素类似物的15,15 - 缩酮。合成与生物活性。
15,15-Ketals of natural prostaglandins and prostaglandin analogues. Synthesis and biological activities.
作者信息
Skuballa W, Radüchel B, Loge O, Elger W, Vorbrüggen H
出版信息
J Med Chem. 1978 May;21(5):443-7. doi: 10.1021/jm00203a007.
PMID:660588
Abstract
The synthesis is described of new 15,15-ethylene ketals of natural prostaglandins and prostaglandin analogues. Especially the crystalline trisamine salt of the 15,15-ethylene ketal of 15-dehydro-16-phenoxy-17,18,19,20-tetranorprostaglandin F2alpha is a very active inducer of luteolysis in laboratory animals and cattle.
摘要
描述了天然前列腺素和前列腺素类似物的新型15,15-亚乙基缩酮的合成。特别是15-脱氢-16-苯氧基-17,18,19,20-四去甲前列腺素F2α的15,15-亚乙基缩酮的结晶三胺盐，在实验动物和牛中是一种非常活跃的黄体溶解诱导剂。
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