15-芳基前列腺素的合成与生物活性

Synthesis and biological activity of 15-arylprostaglandins.

作者信息

Binder D, Bowler J, Crossley N S, Hutton J, King R R, Lilley T J, Senior M W

出版信息

Prostaglandins. 1978 May;15(5):773-8. doi: 10.1016/0090-6980(78)90143-0.

Abstract

Prostaglandin analogues in which the alkyl chain attached to C-15 in the natural compounds is replaced by an aryl group have been synthesised. Some of these compounds are potent luteolytic agents and comparisons are drawn between this series and 16-aryloxyprostaglandins.

摘要

已合成了前列腺素类似物，其中天然化合物中与C-15相连的烷基链被芳基取代。这些化合物中的一些是有效的黄体溶解剂，并对该系列与16-芳氧基前列腺素进行了比较。