一些长效美沙酮哌啶螺环衍生物的合成与镇痛活性
Synthesis and analgesic activity of some long-acting piperidinospiro derivatives of methadone.
作者信息
Frincke J M, Henderson G L
出版信息
J Med Chem. 1978 May;21(5):474-6. doi: 10.1021/jm00203a014.
PMID:660594
Abstract
A congener of methadone, in which the metabolically labile C-6 dimethylamino moiety was replaced with a piperidinospiro derivative, was reduced and acetylated. This conversion produced a marked increase in the duration of analgesia, a trend similar to that found for methadone.
摘要
美沙酮的一种同系物，其中代谢不稳定的C-6二甲基氨基部分被哌啶螺衍生物取代，经还原和乙酰化处理。这种转化使镇痛持续时间显著增加，这一趋势与美沙酮相似。
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