Zagon I S, McLaughlin P J
Experientia. 1980 Mar 15;36(3):329-30. doi: 10.1007/BF01952306.
The analgesic response to the hot-plate test was studied in 21-, 45-, 60-, 120- and 300-day-old rats maternally exposed to methadone (5 mg/kg). An elevation in nociceptive threshold, in the absence of further exposure to methadone, was observed in young and adult rats perinatally subjected to methadone.
在出生前接触美沙酮（5毫克/千克）的21日龄、45日龄、60日龄、120日龄和300日龄大鼠中，研究了对热板试验的镇痛反应。在围产期接触美沙酮的幼年和成年大鼠中观察到，在没有进一步接触美沙酮的情况下，伤害性阈值有所提高。
