Saling E, Malchus R, Hoppe I
J Perinat Med. 1983;11(5):255-7. doi: 10.1515/jpme.1983.11.5.255.
A case is described with two previous unsuccessful pregnancies (one missed abortion and one severe fetal intrauterine growth retardation ending in fetal death). Examination showed that the patient and her husband each share one antigen of the HLA-A and -B series. In spite of two previous pregnancies the patient had no lymphocytotoxic antibodies. The patient then received 5 buffy-coat-pool transfusions and the sera reacted with an increasing number of panel cells (Fig. 1). A mature healthy infant was born at term. We consider that the cytotoxic antibodies achieved, took over a protective function for the later undisturbed progress of the pregnancy. This may be a possible way of preventing intrauterine growth retardation caused by immunologic factors.
本文描述了一个病例，该患者之前有两次妊娠失败（一次稽留流产，一次严重胎儿宫内生长受限并最终胎死宫内）。检查发现患者及其丈夫各自拥有一种HLA - A和 - B系列抗原。尽管之前有过两次妊娠，但患者并无淋巴细胞毒性抗体。随后患者接受了5次浓缩红细胞悬液输注，其血清与越来越多的标准细胞发生反应（图1）。患者足月产下一名健康成熟婴儿。我们认为所产生的细胞毒性抗体承担了保护功能，使得后续妊娠得以顺利进行。这可能是预防免疫因素所致宫内生长受限的一种可行方法。
