Steck T, Westphal E, Würfel W
Department of Obstetrics and Gynecology, University of Würzburg, Federal Republic of Germany.
Arch Gynecol Obstet. 1992;252(2):103-7. doi: 10.1007/BF02389636.
We report a case of repeated fetal death at 31 gestational weeks associated with mild non-proteinuric pre-eclampsia and intrauterine growth retardation. After double intradermal immunisation with paternal leukocytes, a third pregnancy proceeded uneventfully until it ended at 38 weeks. Maternal anti-paternal blocking antibody activity was assessed by the erythrocyte antibody inhibition (EAI) test. Serologic testing revealed that the couple did not share HLA class I antigens. The mechanisms underlying the likely benefit from immunotherapy are discussed.
我们报告一例孕31周反复发生胎儿死亡的病例，该病例与轻度非蛋白尿性先兆子痫及胎儿宫内生长受限相关。经皮内注射两次父亲白细胞免疫后，第三次妊娠顺利进行，直至孕38周结束。通过红细胞抗体抑制（EAI）试验评估母体抗父亲阻断抗体活性。血清学检测显示这对夫妇不共享HLA I类抗原。本文讨论了免疫治疗可能有效的潜在机制。
