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[内囊后肢电刺激治疗丘脑痛]

[Electrical stimulation of the posterior limb of the internal capsule for treatment of thalamic pain].

作者信息

Ohmoto T, Nakao Y, Sakurai M, Asano T, Matsumoto Y, Namba S, Nishimoto A

出版信息

No To Shinkei. 1983 Oct;35(10):1009-16.

PMID:6606434
Abstract

Electrical stimulation of the posterior limb of the internal capsule was performed in six patients with central pain due to vascular lesions of the thalamus. Three patients suffered from thalamic hemorrhage and the other three from ischemic insult. These patients developed dysesthesia, hyperpathia and spontaneous burning pain several months after cerebral vascular diseases. These severe pain were not relieved by any trials of anticonvulsants, psychopharmacological and analgesic drugs. Stimulating electrode system manufactured by Medtronic, Co. was implanted stereo-taxically in the posterior limb of the internal capsule which was 25 mm lateral to the posterior commissure. Ramped bipolar stimulation with a square pulse 2-3 V, 0.2 msec, 50 Hz elicited sensory response such as warm or comfortable sensation. Satisfactory relief of pain was obtained in most cases by 30-minutes-long stimulation twice or three times a day for various period of time ranging from 10 to 14 days. Long-term follow-up ranging from three months to two years showed that three patients had a good result (incomplete pain relief by stimulator with no medication required), two had a fair (incomplete pain relief by stimulator with decreased doses of medication) and another one had a poor result in which the pain had not been relieved with the stimulation in one month. No remarkable side effects were seen. These results indicate that the internal capsule stimulation is more effective and lasts longer than the various ablative methods to relieve central pain.(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

对6例因丘脑血管病变导致中枢性疼痛的患者进行了内囊后肢电刺激。3例患者患有丘脑出血,另外3例患有缺血性损伤。这些患者在脑血管疾病发生数月后出现感觉异常、痛觉过敏和自发性灼痛。任何抗惊厥药、精神药理学药物和镇痛药试验均未能缓解这些严重疼痛。将美敦力公司生产的刺激电极系统立体定向植入内囊后肢,该部位位于后连合外侧25毫米处。用2 - 3伏、0.2毫秒、50赫兹的方波进行斜坡双极刺激可引发感觉反应,如温暖或舒适感。在大多数情况下,通过每天两次或三次30分钟的刺激,持续10至14天的不同时间段,疼痛得到了满意缓解。长达三个月至两年的长期随访显示,3例患者效果良好(刺激器可不完全缓解疼痛,无需用药),2例效果尚可(刺激器可不完全缓解疼痛,用药剂量减少),另一例效果不佳,刺激一个月后疼痛仍未缓解。未观察到明显副作用。这些结果表明,与各种毁损性方法相比,内囊刺激在缓解中枢性疼痛方面更有效且持续时间更长。(摘要截断于250字)

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