Pease C T, Currey H L
Br J Rheumatol. 1983 Nov;22(4 Suppl 2):172-6. doi: 10.1093/rheumatology/xxii.suppl_2.172.
Polymorphonuclear leucocyte functions were tested in 29 patients with ankylosing spondylitis (AS). Twenty of these were HLA-B27 positive and 9 B27 negative. Thirty matched controls were also studied and of these, 15 were B27 negative. Random and directed cell migration were measured both by migration through a micropore filter and also by migration under an agar film. The attractant was serum activated either by casein or by zymosan. By both techniques, directed motility (chemotaxis) was increased in subjects with B27 and/or AS when compared with the B27 negative controls. This suggests that the disease AS and the possession of B27 are both associated with increased chemotaxis.
对29例强直性脊柱炎（AS）患者的多形核白细胞功能进行了检测。其中20例为HLA - B27阳性，9例为B27阴性。还研究了30例匹配的对照者，其中15例为B27阴性。通过微孔滤膜迁移以及琼脂膜下迁移两种方法测量随机和定向细胞迁移。趋化剂是由酪蛋白或酵母聚糖激活的血清。通过这两种技术，与B27阴性对照相比，B27阳性和/或AS患者的定向运动（趋化性）增加。这表明AS疾病和B27阳性均与趋化性增加有关。
