多形核细胞运动、强直性脊柱炎与HLA B27
Polymorphonuclear cell motility, ankylosing spondylitis, and HLA B27.
作者信息
Pease C T, Fordham J N, Currey H L
出版信息
Ann Rheum Dis. 1984 Apr;43(2):279-84. doi: 10.1136/ard.43.2.279.
Abstract
Polymorphonuclear leucocyte (PMN) function was studied in 29 subjects with ankylosing spondylitis (AS). Of these, 20 were HLA B27+ve and 9 B27-ve. There were 30 controls and, of these, 15 were B27+ve. Random and directed cell migration was measured by 2 techniques: migration through a micropore filter and migration under an agar film. The chemo-attractant was either case in-activated serum or zymosan-activated serum. By both techniques directed motility was increased in subjects with B27 or with AS when compared to the B27-ve controls. This suggests that the disease AS and the possession of B27 are both associated with increased PMN motility.
摘要
对29例强直性脊柱炎（AS）患者的多形核白细胞（PMN）功能进行了研究。其中，20例为HLA B27阳性，9例为B27阴性。有30名对照者，其中15例为B27阳性。通过两种技术测量随机和定向细胞迁移：通过微孔滤膜迁移和在琼脂膜下迁移。趋化剂为病例灭活血清或酵母聚糖激活血清。与B27阴性对照相比，通过这两种技术，B27阳性或AS患者的定向运动能力均增强。这表明AS疾病和B27的存在均与PMN运动能力增强有关。
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