Pease C T, Fennell M, Brewerton D A
Department of Rheumatology, Westminster Hospital, London.
Ann Rheum Dis. 1989 Jan;48(1):35-41. doi: 10.1136/ard.48.1.35.
The polymorphonuclear leucocyte (PMN) response to a chemotactic or chemokinetic stimulus is enhanced in men with ankylosing spondylitis (AS). This effect does not parallel the severity of disease activity or the size of the acute phase response, and it is independent of non-steroidal anti-inflammatory drug treatment. Polymorph function is normal in HLA-B27 positive brothers of probands with AS and in other HLA-B27 positive individuals in the absence of disease. Polymorph motility is also normal in patients with psoriasis vulgaris or Crohn's disease, indicating that enhanced PMN motility is not a non-specific consequence of all inflammatory disorders.
强直性脊柱炎（AS）男性患者对趋化性或趋动性刺激的多形核白细胞（PMN）反应增强。这种效应与疾病活动的严重程度或急性期反应的大小不平行，并且独立于非甾体抗炎药治疗。在患有AS的先证者的HLA - B27阳性兄弟以及无疾病的其他HLA - B27阳性个体中，多形核白细胞功能正常。寻常型银屑病或克罗恩病患者的多形核白细胞运动性也正常，这表明PMN运动性增强并非所有炎症性疾病的非特异性后果。
