Fischer S M, Viaje A, Mills G D, Wong E W, Weeks C E, Slaga T J
Carcinogenesis. 1984 Jan;5(1):109-12. doi: 10.1093/carcin/5.1.109.
The tumor promoter 12-O-tetradecanoyl phorbol-13-acetate (TPA) does not stimulate the growth of human epidermal cells in foreskin explant cultures; a dose-dependent inhibition is seen at doses higher than 10(-5) micrograms/ml. TPA also inhibits epidermal growth factor-stimulated growth and does not induce ornithine decarboxylase activity or increase polyamine levels. This is not due to the rapid breakdown of TPA, since TPA is not metabolized to any appreciable extent.
肿瘤促进剂12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯（TPA）在包皮外植体培养中不会刺激人表皮细胞的生长；在高于10^(-5)微克/毫升的剂量下会出现剂量依赖性抑制。TPA还会抑制表皮生长因子刺激的生长，并且不会诱导鸟氨酸脱羧酶活性或增加多胺水平。这并非由于TPA的快速分解，因为TPA在任何可观程度上都不会被代谢。
