大环内酯类抗生素对小鼠巴比妥睡眠时间的影响。
Effects of macrolide antibiotics on barbiturate sleeping time in mice.
作者信息
Descotes J, Evreux J C
出版信息
Experientia. 1983 Dec 15;39(12):1389-90. doi: 10.1007/BF01990119.
PMID:6606586
Abstract
Triacetyloleandomycin and josamycin, when administered to inbred Balb/c mice orally twice daily at a dose of 12.5 or 25 mg per kg over 3 days, were found to increase barbiturate sleeping time significantly. In contrast, erythromycin ethylsuccinate, erythromycin propionate, midecamycin and spiramycin were devoid of any such activity under the same conditions.
摘要
对近交系Balb/c小鼠每日口服两次醋竹桃霉素和交沙霉素，剂量为每千克12.5或25毫克，连续给药3天，结果发现巴比妥类睡眠时间显著延长。相比之下，在相同条件下，琥乙红霉素、丙酸红霉素、麦迪霉素和螺旋霉素则无此活性。
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