Hypoactivity of cytochrome P-450 after triacetyloleandomycin administration.

作者信息

Pessayre D, Konstantinova-Mitcheva M, Descatoire V, Cobert B, Wandscheer J C, Level R, Feldmann G, Mansuy D, Benhamou J P

出版信息

Biochem Pharmacol. 1981 Mar 15;30(6):559-64. doi: 10.1016/0006-2952(81)90126-x.

DOI:10.1016/0006-2952(81)90126-x

PMID:6973978

Abstract

摘要

相似文献

Hypoactivity of cytochrome P-450 after triacetyloleandomycin administration.

Biochem Pharmacol. 1981 Mar 15;30(6):559-64. doi: 10.1016/0006-2952(81)90126-x.

[Effect of triacetyloleandomycin, erythromycin and spiramycin on mono-oxygenase activity].[三乙酰竹桃霉素、红霉素和螺旋霉素对单加氧酶活性的影响]

Eksp Med Morfol. 1984;23(1):28-33.

Self-induction by oleandomycin of its own transformation into a metabolite forming an inactive complex with reduced cytochrome P-450. Comparison with troleandomycin.

J Pharmacol Exp Ther. 1982 Apr;221(1):215-21.

Induction of cytochrome P-450 in rat liver by the antibiotic troleandomycin: partial purificaton and properties of cytochrome P-450-troleandomycin metabolite complexes.抗生素三乙酰竹桃霉素对大鼠肝脏细胞色素P - 450的诱导作用：细胞色素P - 450 - 三乙酰竹桃霉素代谢物复合物的部分纯化及性质

Biochem Biophys Res Commun. 1981 Dec 31;103(4):1201-8. doi: 10.1016/0006-291x(81)90250-3.

Inhibition of rat liver estrogen 2/4-hydroxylase activity by troleandomycin: comparison with erythromycin and roxithromycin.

J Pharmacol Exp Ther. 1990 Sep;254(3):1120-7.

Induction by triacetyloleandomycin and partial purification of a LM3 form of cytochrome P-450 from rabbit liver microsomes.

Biochem Biophys Res Commun. 1982 Feb 11;104(3):1011-7. doi: 10.1016/0006-291x(82)91350-x.

Protection of ethanol-mediated acetaminophen hepatotoxicity by triacetyloleandomycin, a specific inhibitor of CYP3A.三乙酰竹桃霉素（一种CYP3A的特异性抑制剂）对乙醇介导的对乙酰氨基酚肝毒性的保护作用

Ann Clin Lab Sci. 1997 Jan-Feb;27(1):57-62.

Formation of an inactive cytochrome P-450 Fe(II)-metabolite complex after administration of troleandomycin in humans.在人体中服用醋竹桃霉素后形成无活性的细胞色素P-450 Fe(II)-代谢物复合物。

Biochem Pharmacol. 1982 May 1;31(9):1699-704. doi: 10.1016/0006-2952(82)90671-2.

The cytochrome P-450 metabolite complex derived from troleandomycin: properties in vitro and stability in vivo.由醋竹桃霉素衍生而来的细胞色素P - 450代谢物复合物：体外特性及体内稳定性

Chem Biol Interact. 1984 Oct;51(3):371-6. doi: 10.1016/0009-2797(84)90162-5.

Comparative studies of in vitro inhibition of cytochrome P450 3A4-dependent testosterone 6beta-hydroxylation by roxithromycin and its metabolites, troleandomycin, and erythromycin.罗红霉素及其代谢产物醋竹桃霉素和红霉素对细胞色素P450 3A4依赖性睾酮6β-羟基化体外抑制作用的比较研究。

Drug Metab Dispos. 1998 Nov;26(11):1053-7.

引用本文的文献

Numerical analysis of time-dependent inhibition kinetics: comparison between rat liver microsomes and rat hepatocyte data for mechanistic model fitting.时间依赖性抑制动力学的数值分析：用于机制模型拟合的大鼠肝微粒体和大鼠肝细胞数据之间的比较。

Xenobiotica. 2020 Nov;50(11):1301-1310. doi: 10.1080/00498254.2017.1345020. Epub 2020 Aug 24.

Modulation of P450-dependent ifosfamide pharmacokinetics: a better understanding of drug activation in vivo.细胞色素P450依赖的异环磷酰胺药代动力学的调节：对体内药物活化的更好理解。

Br J Cancer. 1998 Jun;77(11):1768-76. doi: 10.1038/bjc.1998.295.

Clarithromycin clinical pharmacokinetics.克拉霉素的临床药代动力学。

Clin Pharmacokinet. 1993 Sep;25(3):189-204. doi: 10.2165/00003088-199325030-00003.

Effect of multiple administration of orphenadrine or mono-N-desmethylorphenadrine on cytochrome P-450 catalyzed reactions in the rat.多次给予奥芬那君或单-N-去甲基奥芬那君对大鼠细胞色素P-450催化反应的影响。

Arch Toxicol. 1983 Oct;54(2):131-7. doi: 10.1007/BF01261381.

Effects of macrolide antibiotics on barbiturate sleeping time in mice.大环内酯类抗生素对小鼠巴比妥睡眠时间的影响。

Experientia. 1983 Dec 15;39(12):1389-90. doi: 10.1007/BF01990119.

Interaction of dihydroergotamine and triacetyloleandomycin in the minipig.

Eur J Drug Metab Pharmacokinet. 1983 Jul-Sep;8(3):261-7. doi: 10.1007/BF03188756.

Pharmacokinetic interactions of the macrolide antibiotics.大环内酯类抗生素的药代动力学相互作用。

Clin Pharmacokinet. 1985 Jan-Feb;10(1):63-79. doi: 10.2165/00003088-198510010-00003.

Methylprednisolone versus prednisolone pharmacokinetics in relation to dose in adults.成人中甲基泼尼松龙与泼尼松龙的药代动力学与剂量的关系

Eur J Clin Pharmacol. 1986;30(3):323-9. doi: 10.1007/BF00541537.

Troleandomycin effects on methylprednisolone and methylprednisone interconversion and disposition in the rabbit.

Eur J Drug Metab Pharmacokinet. 1987 Jan-Mar;12(1):50-7. doi: 10.1007/BF03189861.

Effect of miocamycin on theophylline kinetics in children.

Eur J Clin Pharmacol. 1987;31(6):701-4. doi: 10.1007/BF00541298.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验