内毒素诱导癌症患者单核细胞在体外释放白细胞介素-1：与疾病分期的关系。
Endotoxin-induced in vitro release of interleukin-1 by cancer patients' monocytes: relation to stage of disease.
作者信息
Pollack S, Micali A, Kinne D W, Enker W E, Geller N, Oettgen H F, Hoffmann M K
出版信息
Int J Cancer. 1983 Dec 15;32(6):733-6. doi: 10.1002/ijc.2910320613.
PMID:6606627
Abstract
The in vitro release of IL-1 by monocytes in response to endotoxin was subnormal in many patients with breast cancer, malignant melanoma or colorectal cancer but not in patients with benign tumors of the breast or colon. In each of these groups, IL-1 release was low in patients with early cancer, normal in patients with regional metastases, and low in patients with disseminated cancer.
摘要
许多乳腺癌、恶性黑色素瘤或结直肠癌患者中，单核细胞对内毒素反应产生白细胞介素-1（IL-1）的体外释放低于正常水平，但乳腺或结肠良性肿瘤患者则不然。在这些组中的每一组中，早期癌症患者的IL-1释放较低，区域转移患者正常，而播散性癌症患者则较低。
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