de Leon M J, George A E, Ferris S H, Christman D R, Fowler J S, Gentes C I, Brodie J, Reisberg B, Wolf A P
J Comput Assist Tomogr. 1984 Feb;8(1):88-94. doi: 10.1097/00004728-198402000-00017.
The relationship between alterations in brain structure and brain function was studied in vivo in both young and elderly human subjects. Computed tomography revealed significant age-related ventricular and cortical sulcal dilatation. The cortical changes were most closely related to age. Positron emission tomography failed to show regional changes in brain glucose metabolic rate. The results suggest that the normal aging brain undergoes structural atrophic changes without incurring regional metabolic changes. Examination of the correlations between the structural and the metabolic measures revealed no significant relationships. These data are discussed with respect to the significant structure-function relationships that have been reported in Alzheimer disease.
在年轻和老年人类受试者体内研究了脑结构改变与脑功能之间的关系。计算机断层扫描显示与年龄相关的脑室和皮质沟显著扩张。皮质变化与年龄最为密切相关。正电子发射断层扫描未显示脑葡萄糖代谢率的区域变化。结果表明，正常衰老的大脑会发生结构性萎缩变化，而不会出现区域代谢变化。对结构和代谢指标之间的相关性进行检查，未发现显著关系。结合阿尔茨海默病中已报道的显著结构 - 功能关系对这些数据进行了讨论。
