计算机断层扫描和正电子发射断层扫描对正常衰老和阿尔茨海默病的评估。

Computed tomography and positron emission transaxial tomography evaluations of normal aging and Alzheimer's disease.

作者信息

de Leon M J, Ferris S H, George A E, Reisberg B, Christman D R, Kricheff I I, Wolf A P

出版信息

J Cereb Blood Flow Metab. 1983 Sep;3(3):391-4. doi: 10.1038/jcbfm.1983.57.

DOI:10.1038/jcbfm.1983.57

Abstract

Young normal subjects, old normal subjects, and patients with senile dementia of the Alzheimer's type (SDAT) were studied with both computed tomography (CT) and positron emission transaxial tomography (PETT). Increases in ventricular size with both aging and disease were measured. Regional glucose metabolic rate was not affected by age, but was markedly reduced in SDAT patients. These data indicate that in normal aging, structural brain changes may be more salient than biochemical changes. Although both structural and biochemical changes occur in SDAT, the biochemical changes are more marked. The results suggest that PETT is potentially more useful than CT in the in vivo diagnosis of SDAT.

摘要

对年轻正常受试者、老年正常受试者以及阿尔茨海默型老年痴呆症（SDAT）患者进行了计算机断层扫描（CT）和正电子发射断层扫描（PETT）研究。测量了衰老和疾病导致的脑室大小增加情况。局部葡萄糖代谢率不受年龄影响，但在SDAT患者中显著降低。这些数据表明，在正常衰老过程中，脑结构变化可能比生化变化更显著。虽然SDAT中结构和生化变化都存在，但生化变化更为明显。结果表明，在SDAT的活体诊断中，PETT可能比CT更有用。