Müller-Hermelink H K, Stein H, Steinmann G, Lennert K
Am J Surg Pathol. 1983 Dec;7(8):849-62.
In 1958, a medium-sized cell was recognized in human lymph nodes and found to occur in clusters in about one out of every 10 cases of reactive hyperplasia. At first, it was interpreted as a lymphoblast. Later, electron-microscopic investigations revealed that the cell contained abundant rough endoplasmic reticulum and was apparently restricted to T-regions of lymph nodes. Recently, it was possible to analyze a malignant lymphoma uniformly composed of such cells with a panel of monoclonal antibodies. The cells proved to be Leu-1+, OKT4+, Leu-3a+, HLA-DR+, and weakly reactive with VIL-A1 (antibody to common ALL antigen) and clone F8-11-13, but negative for OKT3, OKT11, OKT8, cytoplasmic immunoglobulin, common B-cell antigen, and C3b receptors. Short-term, in vitro cultures of lymphoma cells showed weak responses to phytohemagglutinin and Interleukin 2 (IL2), but no IL2 production. Lymphoma cells had a low spontaneous proliferation rate (about 2% Ki-67+ cells). In view of these findings, the term "plasma-cytoid T-cell" is proposed. A functional relationship between these cells and the myeloid system was suggested because the patient developed a myelomonocytic leukemia 3 months after the diagnosis of malignant lymphoma was made.
1958年，在人类淋巴结中识别出一种中等大小的细胞，发现其在每10例反应性增生病例中约有1例呈簇状出现。起初，它被解释为成淋巴细胞。后来，电子显微镜研究显示该细胞含有丰富的粗面内质网，且明显局限于淋巴结的T区。最近，利用一组单克隆抗体有可能分析出一种由这类细胞均匀组成的恶性淋巴瘤。这些细胞被证明为Leu-1+、OKT4+、Leu-3a+、HLA-DR+，与VIL-A1（抗常见ALL抗原抗体）和克隆F8-11-13反应较弱，但对OKT3、OKT11、OKT8、细胞质免疫球蛋白、常见B细胞抗原和C3b受体呈阴性。淋巴瘤细胞的短期体外培养显示对植物血凝素和白细胞介素2（IL2）反应较弱，但不产生IL2。淋巴瘤细胞的自发增殖率较低（约2%的Ki-67+细胞）。鉴于这些发现，提出了“浆细胞样T细胞”这一术语。由于该患者在恶性淋巴瘤诊断后3个月发生了骨髓单核细胞白血病，提示这些细胞与髓系系统之间存在功能关系。
