Beiske K, Langholm R, Godal T, Marton P F
J Pathol. 1986 Dec;150(4):247-55. doi: 10.1002/path.1711500404.
In this paper we present a further case of a new clinicopathological entity combining a rare type of non-Hodgkin lymphoma with a myelomonocytic leukaemia. The characteristic feature of the lymphoma is massive infiltration of the T-zones of lymph nodes by plasmacytoid cells originally described by Lennert in non-specific lymphadenitis. Two lymphoma cases of this type have recently been published, by Müller-Hermelink et al. who named the cells 'plasmacytoid T-cells' (PTC), and by Prasthofer et al. These three cases have similar clinical and pathological features and appear to form a distinct clinicopathological entity. In contrast to the two previously published cases the present lymphoma also contained irregular lymphoid cells accompanying the PTC in the lymph node lesion and focally infiltrating the bone marrow. An accumulation of polytypic IgG positive plasma cells was observed in the remaining lymph node follicles. Immunohistological analysis with a range of monoclonal antibodies showed the PTC of our case to be CD5(T1)+, CD4(T4)+, CD3(T3)-, CD8(T8)-, CD2(T11)-, and CD25(TAC)-, but HLA-DR+ and transferrin receptor positive. The nature of this peculiar lymphoid lesion and its relationship to myelomonocytic leukaemia are discussed.
在本文中，我们报告了另一例新的临床病理实体病例，该病例将一种罕见类型的非霍奇金淋巴瘤与骨髓单核细胞白血病合并在一起。淋巴瘤的特征性表现是淋巴结的T区被浆细胞样细胞大量浸润，这种细胞最初由伦纳特在非特异性淋巴结炎中描述。最近，米勒 - 赫梅林克等人以及普拉施托费尔等人分别发表了两例这种类型的淋巴瘤病例，他们将这些细胞命名为“浆细胞样T细胞”（PTC）。这三例病例具有相似的临床和病理特征，似乎构成了一个独特的临床病理实体。与之前发表的两例病例不同，本病例中的淋巴瘤在淋巴结病变中还含有不规则淋巴细胞，这些淋巴细胞伴随PTC并局部浸润骨髓。在剩余的淋巴结滤泡中观察到多型性IgG阳性浆细胞的聚集。使用一系列单克隆抗体进行免疫组织学分析显示，我们病例中的PTC为CD5（T1）+、CD4（T4）+、CD3（T3）-、CD8（T8）-、CD2（T11）-和CD25（TAC）-，但HLA - DR +且转铁蛋白受体阳性。本文讨论了这种特殊淋巴病变的性质及其与骨髓单核细胞白血病的关系。
