Kumar M, Gupta R M, Nema H V
Ann Ophthalmol. 1983 Sep;15(9):838-40.
Twenty-five cases of retinitis pigmentosa were investigated to assess the cell-mediated immunity and for evidence of autoimmunity by measuring peripheral blood T-cell rosette count, cutaneous DTH response to recall antigens (Candida and purified protein derivative [PPD]), and 2:4 dinitrochlorobenzene (DNCB) and antiretinal antibody by tanned red cell hemagglutination technique. It was observed that cell-mediated immunity was significantly depressed, and antiretinal antibody was found in 60% of the cases, which correlated with the duration and severity of the disease. We conclude that although retinitis pigmentosa is genetically determined, patients develop autoimmunity against retinal tissue due to suppression of cell-mediated immunity. Association of rheumatoid factor in 8% of the cases further confirms the loss of homeostatic control owing to suppressed cell-mediated immunity.
对25例色素性视网膜炎患者进行了研究，通过检测外周血T细胞玫瑰花结计数、对回忆抗原（白色念珠菌和纯化蛋白衍生物[PPD]）的皮肤迟发型超敏反应（DTH）以及采用鞣酸红细胞血凝技术检测2,4-二硝基氯苯（DNCB）和抗视网膜抗体，来评估细胞介导的免疫功能及自身免疫证据。观察到细胞介导的免疫功能显著降低，60%的病例中发现了抗视网膜抗体，且其与疾病的病程和严重程度相关。我们得出结论，尽管色素性视网膜炎由基因决定，但由于细胞介导的免疫功能受到抑制，患者会产生针对视网膜组织的自身免疫。8%的病例中类风湿因子呈阳性，进一步证实了由于细胞介导的免疫功能受抑制导致体内稳态控制失衡。
