Heckenlively J R, Solish A M, Chant S M, Meyers-Elliott R H
Br J Ophthalmol. 1985 Oct;69(10):758-64. doi: 10.1136/bjo.69.10.758.
Testing by indirect immunofluorescence for the detection of antiretinal antibodies and lymphocyte stimulation for cell-mediated immunity to retinal antigens was performed on blood obtained from 59 patients with retinitis pigmentosa (RP) and 29 without RP who had other types of retinal disease. The results from the patients' immunological studies were correlated in a masked fashion with six parameters of the fluorescein angiogram: disc staining, peripapillary oedema, vascular arcade oedema, macular oedema, and focal vascular staining (late phases), and disc telangiectasia (early phases). Significant correlations for both groups together were found for IgG antiretinal antibody reactivity and macular oedema (p less than 0.038) and disc staining (p less than 0.033). The non-RP retinal disease group had more significant correlations, including IgG antiretinal antibody reactivity with vascular arcade oedema (p less than 0.018), disc staining (p less than 0.018), and peripapillary oedema (p less than 0.023); the RP patients had significant correlation with IgG reactivity and arcade oedema (p less than 0.045). With combinations of IgG, IgM, and lymphocyte reactivity various significant correlations were found with the fluorescein angiogram.
对59例色素性视网膜炎（RP）患者以及29例患有其他类型视网膜疾病但无RP的患者采集的血液进行间接免疫荧光检测以检测抗视网膜抗体，并进行淋巴细胞刺激试验以检测针对视网膜抗原的细胞介导免疫。患者免疫研究的结果以盲法与荧光素血管造影的六个参数相关联：视盘染色、视盘周围水肿、血管弓水肿、黄斑水肿、局灶性血管染色（晚期）以及视盘毛细血管扩张（早期）。两组患者的IgG抗视网膜抗体反应性与黄斑水肿（p<0.038）和视盘染色（p<0.033）均存在显著相关性。非RP视网膜疾病组的相关性更为显著，包括IgG抗视网膜抗体反应性与血管弓水肿（p<0.018）、视盘染色（p<0.018）和视盘周围水肿（p<0.023）；RP患者的IgG反应性与血管弓水肿存在显著相关性（p<0.045）。IgG、IgM和淋巴细胞反应性的组合与荧光素血管造影存在各种显著相关性。
