一名XYY男性患有的伴有复杂Ph1易位的慢性粒细胞白血病。

Chronic myelogenous leukemia with a complex Ph1 translocation in an XYY male.

作者信息

Ohyashiki K, Oshimura M, Toyoda T, Sakai N, Ito H, Yamamoto K, Tonomura A

出版信息

Cancer Genet Cytogenet. 1984 Feb;11(2):215-9. doi: 10.1016/0165-4608(84)90115-8.

Abstract

We encountered a 38-year-old Japanese male patient with chronic myelogenous leukemia (CML), whose bone marrow and peripheral blood cells during the chronic and blastic phases contained a complex Ph1 translocation and an extra Y chromosome [i.e., 47,XYY,t(9;22;13)(q34;q11;q14)]. A karyotypic analysis of PHA-stimulated lymphocytes showed the constitutional karyotype to be 47,XYY. Thus, it was considered that CML with a complex Ph1 translocation developed in an XYY male; such a case has not been reported, so far. A B-lymphocyte cell line with the complex Ph1 translocation was established by the procedure of Epstein-Barr virus transformation. The presence of the complex Ph1 translocation in the B-lymphocyte cell line suggests that some of the B lymphocytes in this patient originated from the CML clone.

摘要

我们遇到了一名38岁的日本男性慢性粒细胞白血病（CML）患者，其慢性期和急变期的骨髓及外周血细胞含有复杂的费城染色体易位及一条额外的Y染色体[即47,XYY,t(9;22;13)(q34;q11;q14)]。对PHA刺激的淋巴细胞进行的核型分析显示其染色体组核型为47,XYY。因此，认为在一名XYY男性中发生了伴有复杂费城染色体易位的慢性粒细胞白血病；迄今为止，尚未有此类病例的报道。通过爱泼斯坦-巴尔病毒转化程序建立了具有复杂费城染色体易位的B淋巴细胞系。B淋巴细胞系中存在复杂的费城染色体易位提示该患者的一些B淋巴细胞起源于慢性粒细胞白血病克隆。