Drumev D, Vangelov S, Pashov D, Iovchev E, Avramova N, Vŭlchanova R
Vet Med Nauki. 1983;20(9):87-95.
Investigations were carried out with a total of 421 broiler birds (four-line Cornish X Plymouth Rock hydbrids) within the age range of 2 days to 5 weeks. Determined was the acute toxicity of the combination sulfadimidine (SDM) + trimetoprim (TMP)--5 + 1 and the water-soluble formula of trimedin following the intraingluvial introduction with week-old birds. LD50 of the combinations SDM+TMP (5+1) was 3980 mg/kg (2780: 5690), and that of trimedin was 2038 mg/kg body mass. The biologic half-life of SDM ranged from 4.77 to 5.34 h, and that of TMP--from 4.81 to 5.71 h at the intraingluvial introduction of the combination SDM+TMP (5+1) at the rate of 0.06 g/kg. Demonstrated were the therapeutic levels of SDM and TMP during the whole period (10 days) of treatment with the combination SDM+TMP (5+1) given with the feed in conc. 500 ppm or at the application of trimedin alone via the drinking water in conc. 0.05%. It was found that trimedin used for 10 days with the drinking water in conc. 0.05 per cent with broilers at the experimental infection with Salmonella gallinarum-pullorum protected about 40 per cent of the birds, the latter remaining, however, carriers of the infection.
对421只2日龄至5周龄的肉鸡（四系康尼什X普利茅斯洛克杂交鸡）进行了研究。测定了磺胺二甲嘧啶（SDM）+甲氧苄啶（TMP）——5+1组合以及三甲嘧啶水溶性配方在一周龄雏鸡经嗉囊内注射后的急性毒性。SDM+TMP（5+1）组合的半数致死量（LD50）为3980毫克/千克（2780：5690），三甲嘧啶的半数致死量为2038毫克/千克体重。在以0.06克/千克的剂量经嗉囊内注射SDM+TMP（5+1）组合时，SDM的生物半衰期为4.77至5.34小时，TMP的生物半衰期为4.81至5.71小时。在以500 ppm的浓度通过饲料给予SDM+TMP（5+1）组合或单独以0.05%的浓度通过饮用水给予三甲嘧啶进行为期10天的治疗期间，显示了SDM和TMP的治疗水平。结果发现，在实验性感染鸡白痢沙门氏菌的肉鸡中，以0.05%的浓度通过饮用水给予三甲嘧啶10天，可保护约40%的鸡，但这些鸡仍为感染携带者。
