Drumev D, Vangelov S, Mutafchieva R, Loseva M, Dzhurov A
Vet Med Nauki. 1982;19(9):100-6.
Investigated were the acute toxicity, serum concentrations, and residual amounts of doxycycline in broiler chickens. It was found that the LD50 of doxycycline when applied via the crop to week-old broiler birds was 2500 mg/kg mass. The amount of 0.005 g/kg mass given orally to birds led to serum concentrations that on the eighteenth hour were found to drop up to subtherapeutic ones. When applied with the drinking water at the rate of 0.02 to 0.04 g l or kg feed it was well absorbed as early as the first hours. In such case the drug maintained therapeutic concentrations that were higher in the internal organs than those in the serum. The residual amounts of doxicycline hydrochloride when it was applied at 0.04 g/l of water or kg feed were found up to 48 h hour by the method of agar diffusion, using Bac. subtilis L2 as a test organism. The withdrawal time should amount to 72 hours.
对肉鸡进行了多西环素的急性毒性、血清浓度和残留量研究。结果发现，通过嗉囊给1周龄肉鸡使用多西环素时，其半数致死量为2500毫克/千克体重。给鸡口服0.005克/千克体重的剂量，在第18小时时血清浓度降至亚治疗浓度。以0.02至0.04克/升或千克饲料的比例与饮用水混合使用时，早在最初几个小时就被很好地吸收。在这种情况下，药物在体内器官中维持的治疗浓度高于血清中的浓度。采用枯草芽孢杆菌L2作为测试菌株，通过琼脂扩散法发现，当以0.04克/升水或千克饲料的剂量使用盐酸多西环素时，其残留量可持续至48小时。休药期应为72小时。
