Chuang V P
AJR Am J Roentgenol. 1984 Feb;142(2):385-8. doi: 10.2214/ajr.142.2.385.
Angiography has proved to be a useful adjuvant to management of advanced cancer. By arterial infusion, greater tumor response to drugs may be achieved than by systemic administration. In osteosarcomas, improved control of primary tumors by intraarterial drug therapy (n = 53) permitted more frequent limb salvage procedures, and, in advanced bladder cancer (n = 18), pain and hematuria were controlled in the majority. Some brain tumors (n = 30), failing control by other methods, have responded to intraarterial chemotherapy. Arterial embolization is also useful for tumor control in combination with surgery and chemotherapy. In unresectable giant cell tumors of bone and aneurysmal bone cyst, pain relief and tumor regression occurred in over half the patients. In hepatic tumors, failing control by intraarterial drug infusion, embolization of the tumor extended survival. A brief description of new methods for intravascular delivery of chemotherapeutic drugs completes this overview of experience at M.D. Anderson Hospital with angiographic cancer therapy.
血管造影术已被证明是晚期癌症治疗的一种有用辅助手段。通过动脉灌注，与全身给药相比，肿瘤对药物的反应可能更大。在骨肉瘤中，通过动脉内药物治疗（n = 53）对原发性肿瘤的更好控制使得保肢手术更频繁地进行，并且在晚期膀胱癌（n = 18）中，大多数患者的疼痛和血尿得到了控制。一些通过其他方法无法控制的脑肿瘤（n = 30）对动脉内化疗有反应。动脉栓塞术与手术和化疗联合使用对肿瘤控制也很有用。在不可切除的骨巨细胞瘤和动脉瘤样骨囊肿中，超过一半的患者疼痛缓解且肿瘤缩小。在肝肿瘤中，动脉内药物灌注无法控制时，肿瘤栓塞可延长生存期。本文简要介绍了血管内化疗药物递送的新方法，完成了MD安德森医院血管造影术癌症治疗经验的概述。
