Parker M S, Dokoh S, Woolfenden J M, Buchsbaum H W
Am J Med. 1984 Feb;76(2):341-4. doi: 10.1016/0002-9343(84)90799-x.
Two patients with disseminated coccidioidomycosis and hypercalcemia are presented. One patient studied showed normal levels of 25-hydroxyvitamin D with depressed levels of 1 alpha,25-dihydroxyvitamin D. The serum calcitonin level was appropriate for the level of serum calcium, and the serum parathyroid hormone level was suppressed with elevation of the nephrogenous cAMP level. Intestinal absorption of calcium was elevated at 63 percent. Hypercalcemia and hypercalciuria persisted despite a 300 mg calcium diet. An osteotropic substance similar to the humoral hypercalcemia of malignancy is postulated.
本文报告了两名播散性球孢子菌病合并高钙血症的患者。其中一名接受研究的患者25-羟维生素D水平正常，但1α,25-二羟维生素D水平降低。血清降钙素水平与血清钙水平相符，血清甲状旁腺激素水平受到抑制，同时肾源性环磷酸腺苷水平升高。肠道钙吸收升高至63%。尽管饮食中钙含量为300毫克，但高钙血症和高钙尿症仍持续存在。推测存在一种类似于恶性肿瘤体液性高钙血症的促骨物质。
