Heiman D F, Haas M, Griffiths J K, Bia F J
Yale J Biol Med. 1984 Sep-Oct;57(5):787-95.
Some of the problems which we see on the infectious disease consultation service can be quite frustrating. This is one such case. A middle-aged man presented to our medical service with fever and dyspnea. His fulminant downhill course was characterized by anemia, jaundice, hypercalcemia, pulmonary abnormalities, and a lack of responsiveness to conventional antimicrobial therapy. At autopsy, malignant-appearing histiocytes were present in several organs including spleen, lymph nodes, and lung. Histopathological examination of tissues obtained at autopsy confirmed the presence of phagocytized erythrocytes within such histiocytes. This case aptly illustrates the hazy dividing line which sometimes exists between infectious and/or malignant processes which are, at present, still of undetermined etiology.
我们在传染病会诊服务中遇到的一些问题可能会相当令人沮丧。这就是这样一个病例。一名中年男子因发热和呼吸困难前来我们的医疗服务部门就诊。他的病情迅速恶化，其特征为贫血、黄疸、高钙血症、肺部异常，以及对传统抗菌治疗无反应。尸检时，在包括脾脏、淋巴结和肺在内的多个器官中发现了外观呈恶性的组织细胞。对尸检获取的组织进行组织病理学检查证实，这些组织细胞内存在吞噬的红细胞。这个病例恰当地说明了目前病因仍未明确的感染性和/或恶性疾病过程之间有时存在的模糊分界线。
