Galbraith G M, Thiers B H, Vasily D B, Fudenberg H H
Br J Dermatol. 1984 Feb;110(2):163-70. doi: 10.1111/j.1365-2133.1984.tb07462.x.
Cell-mediated immunity and auto-immune phenomena were investigated in sixty patients with active alopecia areata of various degrees of severity. Serum auto-antibodies to thyroid antigens were detected in twenty-three patients. Examination of T-lymphocyte populations, lymphocyte DNA synthesis, and lymphokine production in response to mitogen stimulation revealed no differences between the sixty patients and matched healthy control subjects. However, patients with thyroid auto-immunity and/or the presence of alopecia totalis or universalis showed significant reductions in interactive T lymphocytes (recognized by rosette formation with human B lymphoblastoid cells) and diminished production of leukocyte migration inhibition factor in response to stimulation with phytohaemagglutinin. This suggests that immune mechanisms may be involved in the pathogenesis of alopecia areata which is associated with thyroid auto-immunity or which progresses to total hair loss.
对60名患有不同严重程度活动性斑秃的患者的细胞介导免疫和自身免疫现象进行了研究。在23名患者中检测到了针对甲状腺抗原的血清自身抗体。对T淋巴细胞群体、淋巴细胞DNA合成以及有丝分裂原刺激后淋巴因子产生的检测显示，这60名患者与相匹配的健康对照者之间没有差异。然而，患有甲状腺自身免疫和/或全秃或普秃的患者，其相互作用性T淋巴细胞（通过与人B淋巴母细胞形成玫瑰花结来识别）显著减少，并且在受到植物血凝素刺激后白细胞迁移抑制因子的产生减少。这表明免疫机制可能参与了与甲状腺自身免疫相关或进展为全秃的斑秃的发病过程。
