Friedmann P S
Br J Dermatol. 1981 Aug;105(2):145-51. doi: 10.1111/j.1365-2133.1981.tb01199.x.
T lymphocyte numbers and functions were measured in forty-six patients with alopecia areata and thirty healthy controls. In patients with alopecia areata, lymphocyte reactivity to extracts of scalp and hair follicles was not detected by 3H thymidine incorporation. 3H Thymidine incorporation by lymphocytes cultured with PPD, Varidase and C. albicans was significantly reduced in cells from patients compared with controls and correlated with the extent of hair loss and the presence of antithyroid antibodies. Decreased lymphocyte responses to PPD and Varidase were not due to the presence of suppressor monocytes because removal of monocytes with carbonyl iron did not increase lymphocyte reactivity. However, responsiveness to C. albicans was augmented by removal of monocytes. T cell numbers were significantly lower than in controls (P less than 0.005); patients with auto-antibodies had fewer T cells than patients without them. The relationship of reduced T cell function and auto-immunity to alopecia areata is discussed.
对46例斑秃患者和30名健康对照者的T淋巴细胞数量及功能进行了检测。在斑秃患者中，通过³H胸苷掺入法未检测到淋巴细胞对头皮和毛囊提取物的反应性。与对照组相比，用PPD、溶菌酶和白色念珠菌培养的患者淋巴细胞³H胸苷掺入量显著降低，且与脱发程度和抗甲状腺抗体的存在相关。淋巴细胞对PPD和溶菌酶反应性降低并非由于抑制性单核细胞的存在，因为用羰基铁去除单核细胞并未增加淋巴细胞反应性。然而，去除单核细胞后对白色念珠菌的反应性增强。T细胞数量显著低于对照组（P<0.005）；有自身抗体的患者T细胞比无自身抗体的患者少。本文讨论了T细胞功能降低和自身免疫与斑秃的关系。
