Happle R, Klein H M, Macher E
Arch Dermatol Res. 1986;278(3):214-8. doi: 10.1007/BF00412926.
It has previously been shown that, in patients with untreated progressive alopecia areata (AA), the peribulbar T4/T8 ratio is about 4:1. In the present study, the immunohistochemical findings obtained in untreated AA patients were compared to those obtained in patients who had received topical immunotherapy with diphencyprone. The untreated group consisted of 5 patients with progressive AA and 5 patients with inactive AA. The treated group consisted of 5 patients with a good response to diphencyprone and 5 patients with little or no hair regrowth after treatment. In untreated patients with progressive AA, the mean peribulbar T4/T8 ratio was 4:1, whereas in untreated patients with stable AA, the ratio was 2:1. In the treated patients with a good response to diphencyprone, the mean T4/T8 ratio was 1:1, while in the patients with poor or no response to treatment, the ratio was 0.7. In conclusion, topical immunotherapy considerably alters the peribulbar T4/T8 ratio in AA. The results are consistent with, but do not prove, the concept of topical immunomodulation.
此前已有研究表明，在未经治疗的进展期斑秃（AA）患者中，球周T4/T8比值约为4:1。在本研究中，将未经治疗的AA患者的免疫组化结果与接受二苯环丙烯酮局部免疫治疗的患者的结果进行了比较。未治疗组包括5例进展期AA患者和5例静止期AA患者。治疗组包括5例对二苯环丙烯酮反应良好的患者和5例治疗后几乎没有或没有毛发再生的患者。在未经治疗的进展期AA患者中，球周T4/T8平均比值为4:1，而在未经治疗的静止期AA患者中，该比值为2:1。在对二苯环丙烯酮反应良好的治疗患者中，T4/T8平均比值为1:1，而在对治疗反应不佳或无反应的患者中，该比值为0.7。总之，局部免疫治疗可显著改变AA患者的球周T4/T8比值。这些结果与局部免疫调节的概念一致，但并未证实这一概念。
