Zalewski A A, Gulati A K
Exp Neurol. 1984 Mar;83(3):659-63. doi: 10.1016/0014-4886(84)90134-1.
Although some allografts bearing major and minor transplantation antigens can survive after the cessation of immunosuppression with cyclosporin-A (Cy-A), nerve allografts do not. In an attempt to induce immunological unresponsiveness to nerve allografts, we used grafts containing only minor transplantation antigens and varied the duration of Cy-A therapy from 2 to 12 weeks. Our results demonstrated that nerve allografts survived in rats during Cy-A therapy, but when the drug administration ceased, the allografts were rejected. Other factors besides the degree of histoincompatibility and duration of Cy-A treatment must be involved in determining whether or not unresponsiveness develops to allografts after Cy-A withdrawal. We conclude that nerve allograft immunosuppression generated by Cy-A requires regular administration of the drug.
尽管一些携带主要和次要移植抗原的同种异体移植物在停用环孢素A（Cy-A）免疫抑制后能够存活，但神经同种异体移植物却不能。为了诱导对神经同种异体移植物的免疫无反应性，我们使用了仅含有次要移植抗原的移植物，并将Cy-A治疗的持续时间从2周延长至12周。我们的结果表明，神经同种异体移植物在Cy-A治疗期间在大鼠体内存活，但当停药后，同种异体移植物被排斥。除了组织相容性程度和Cy-A治疗持续时间外，其他因素也必定参与决定停用Cy-A后是否会对同种异体移植物产生无反应性。我们得出结论，Cy-A产生的神经同种异体移植免疫抑制需要定期给药。
